ERCC1

ERCC1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1Z00, 2A1I, 2A1J, 2JNW, 2JPD, 2MUT
Dynodwyr
Cyfenwau	ERCC1, COFS4, RAD10, UV20, excision repair cross-complementation group 1, ERCC excision repair 1, endonuclease non-catalytic subunit
Dynodwyr allanol	OMIM: 126380 HomoloGene: 1501 GeneCards: ERCC1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein domain specific binding; • single-stranded DNA binding; • damaged DNA binding; • single-stranded DNA endodeoxyribonuclease activity; • protein C-terminus binding; • GO:0001948, GO:0016582 protein binding; • TFIID-class transcription factor complex binding; • nuclease activity; • endonuclease activity; • hydrolase activity; • 3' overhang single-stranded DNA endodeoxyribonuclease activity; • DNA binding;
Cydrannau o'r gell	• ERCC4-ERCC1 complex; • transcription factor TFIID complex; • nucleoplasm; • nucleotide-excision repair factor 1 complex; • nucleotide-excision repair complex; • cnewyllyn cell; • cytoplasm; • cytosol;
Prosesau biolegol	• germ cell development; • DNA recombination; • male gonad development; • interstrand cross-link repair; • positive regulation of t-circle formation; • cell development; • response to nutrient; • multicellular organism growth; • embryonic organ development; • post-embryonic hemopoiesis; • syncytium formation; • GO:0001306 response to oxidative stress; • GO:0051312, GO:0007083 chromosome organization; • pyrimidine dimer repair by nucleotide-excision repair; • oogenesis; • cellular response to DNA damage stimulus; • global genome nucleotide-excision repair; • isotype switching; • spermatogenesis; • multicellular organism aging; • UV protection; • t-circle formation; • negative regulation of telomere maintenance; • transcription-coupled nucleotide-excision repair; • mitotic recombination; • cell population proliferation; • nucleotide-excision repair, DNA incision; • response to X-ray; • response to sucrose; • nucleotide-excision repair; • nucleotide-excision repair, preincision complex stabilization; • double-strand break repair; • GO:0100026 DNA repair; • nucleotide-excision repair, DNA incision, 5'-to lesion; • nucleotide-excision repair, DNA incision, 3'-to lesion; • meiotic mismatch repair; • double-strand break repair via nonhomologous end joining; • UV-damage excision repair; • negative regulation of protection from non-homologous end joining at telomere; • telomeric DNA-containing double minutes formation; • response to immobilization stress; • response to cadmium ion; • nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologau
	2067
	n/a
	ENSG00000012061
	n/a
	P07992
	n/a
	NM_001166049; NM_001983; NM_202001
	n/a
NP_001159521; NP_001974; NP_973730; NP_001356337; NP_001356338;
	NP_001356339; NP_001356340; NP_001356341; NP_001356342; NP_001356343; NP_001356344; NP_001356345; NP_001356346; NP_001356347; NP_001356348
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERCC1 yw ERCC1 a elwir hefyd yn DNA excision repair protein ERCC-1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERCC1.

UV20
COFS4
RAD10

Llyfryddiaeth

"Association between the ERCC1 polymorphism and platinum-based chemotherapy effectiveness in ovarian cancer: a meta-analysis. ". BMC Womens Health. 2017. PMID 28623887.
"The Contribution of Excision Repair Cross-complementing Group 1 Genotypes to Colorectal Cancer Susceptibility in Taiwan. ". Anticancer Res. 2017. PMID 28476796.
"Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance. ". Oncol Rep. 2017. PMID 28260069.
"Computed Tomography Manifestations and Excision Cross-Complementation Group 1 Expression of Stage I Non-Small-Cell Lung Cancer and Their Correlation With Prognosis. ". J Comput Assist Tomogr. 2016. PMID 27434787.
"ERCC1 C118T polymorphism has predictive value for platinum-based chemotherapy in patients with late-stage bladder cancer.". Genet Mol Res. 2016. PMID 27323074.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ERCC1 - Cronfa NCBI

[1]

[2]