ERCC4

ERCC4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1Z00, 2A1J, 2MUT, 2KN7, 2AQ0
Dynodwyr
Cyfenwau	ERCC4, ERCC11, FANCQ, RAD1, XPF, XFEPS, excision repair cross-complementation group 4, ERCC excision repair 4, endonuclease catalytic subunit
Dynodwyr allanol	OMIM: 133520 HomoloGene: 3836 GeneCards: ERCC4
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein N-terminus binding; • damaged DNA binding; • protein C-terminus binding; • GO:0001948, GO:0016582 protein binding; • TFIID-class transcription factor complex binding; • nuclease activity; • endonuclease activity; • hydrolase activity; • endodeoxyribonuclease activity; • single-stranded DNA binding; • telomerase inhibitor activity; • 3' overhang single-stranded DNA endodeoxyribonuclease activity; • DNA binding; • identical protein binding; • single-stranded DNA endodeoxyribonuclease activity;
Cydrannau o'r gell	• ERCC4-ERCC1 complex; • transcription factor TFIID complex; • nucleoplasm; • telomere; • nucleotide-excision repair factor 1 complex; • nucleotide-excision repair complex; • cnewyllyn cell;
Prosesau biolegol	• resolution of meiotic recombination intermediates; • interstrand cross-link repair; • cellular response to UV; • cellular response to DNA damage stimulus; • global genome nucleotide-excision repair; • nucleotide-excision repair involved in interstrand cross-link repair; • UV protection; • negative regulation of telomere maintenance; • transcription-coupled nucleotide-excision repair; • nucleotide-excision repair, DNA incision; • telomere maintenance; • response to UV; • double-strand break repair via homologous recombination; • GO:0100026 DNA repair; • nucleotide-excision repair, DNA incision, 3'-to lesion; • nucleotide-excision repair; • nucleotide-excision repair, DNA incision, 5'-to lesion; • nucleotide-excision repair, preincision complex stabilization; • double-strand break repair via nonhomologous end joining; • negative regulation of telomerase activity; • negative regulation of telomere maintenance via telomere lengthening; • negative regulation of protection from non-homologous end joining at telomere; • negative regulation of double-stranded telomeric DNA binding; • telomeric DNA-containing double minutes formation; • regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologau
	2072
	n/a
	ENSG00000175595
	n/a
	Q92889
	n/a
	NM_005236
	n/a
	NP_005227
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERCC4 yw ERCC4 a elwir hefyd yn ERCC excision repair 4, endonuclease catalytic subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p13.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERCC4.

XPF
RAD1
FANCQ
XFEPS
ERCC11

Llyfryddiaeth

"Higher expression of XPF is a critical factor in intrinsic chemotherapy resistance of human renal cell carcinoma. ". Int J Cancer. 2016. PMID 27542841.
"Association of XPF Levels and Genetic Polymorphism with Susceptibility to Ischemic Stroke. ". J Mol Neurosci. 2016. PMID 26888738.
"The Role of the XPF Gene Polymorphism (Xrcc4) Ser835ser in the Risk of Malignant Transformation of Cells in the Colorectal Cancer. ". Pol Przegl Chir. 2015. PMID 26146099.
"Lack of association between XPF polymorphisms and gastric cancer risk: a meta-analysis. ". Oncol Res Treat. 2014. PMID 25342505.
"Associations of ERCC4 rs1800067 polymorphism with cancer risk: an updated meta-analysis.". Asian Pac J Cancer Prev. 2014. PMID 25292041.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ERCC4 - Cronfa NCBI

[1]

[2]