ETV6

ETV6
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1JI7, 1LKY, 2DAO, 2QAR, 2QB0, 2QB1
Dynodwyr
Cyfenwau	ETV6, TEL, TEL/ABL, THC5, ETS variant 6, ETS variant transcription factor 6
Dynodwyr allanol	OMIM: 600618 HomoloGene: 37560 GeneCards: ETV6
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA binding; • sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 protein binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • protein domain specific binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• nucleolus; • cnewyllyn cell; • cytosol;
Prosesau biolegol	• hematopoietic stem cell proliferation; • cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • vitellogenesis; • mesenchymal cell apoptotic process; • neurogenesis; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	2120
	n/a
	ENSG00000139083
	n/a
	P41212
	n/a
	NM_001987
	n/a
	NP_001978
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ETV6 yw ETV6 a elwir hefyd yn ETS variant 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ETV6.

TEL
THC5
TEL/ABL

Llyfryddiaeth

"Next-generation sequencing and molecular cytogenetic characterization of ETV6-LYN fusion due to chromosomes 1, 8 and 12 rearrangement in acute myeloid leukemia. ". Cancer Genet. 2017. PMID 29153093.
"ETV6 Gene Rearrangements Characterize a Morphologically Distinct Subset of Sinonasal Low-grade Non-intestinal-type Adenocarcinoma: A Novel Translocation-associated Carcinoma Restricted to the Sinonasal Tract. ". Am J Surg Pathol. 2017. PMID 28719468.
"Electrostatic control of DNA intersegmental translocation by the ETS transcription factor ETV6. ". J Biol Chem. 2017. PMID 28592487.
"Germline ETV6 mutations and predisposition to hematological malignancies. ". Int J Hematol. 2017. PMID 28555414.
"Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study.". Lancet Oncol. 2015. PMID 26522332.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ETV6 - Cronfa NCBI

[1]

[2]