FAS

FAS
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1DDF, 3EWT, 3EZQ, 3THM, 3TJE, 2NA7
Dynodwyr
Cyfenwau	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6, Fas cell surface death receptor
Dynodwyr allanol	OMIM: 134637 HomoloGene: 27 GeneCards: FAS
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• kinase binding; • GO:0001948, GO:0016582 protein binding; • transmembrane signaling receptor activity; • signal transducer activity; • identical protein binding; • tumor necrosis factor-activated receptor activity; • tumor necrosis factor binding; • calmodulin binding; • signaling receptor activity;
Cydrannau o'r gell	• CD95 death-inducing signaling complex; • bilen; • extracellular region; • cell surface; • extracellular exosome; • integral component of membrane; • Cellbilen; • integral component of plasma membrane; • external side of plasma membrane; • death-inducing signaling complex; • membrane raft; • cytosol; • nuclear body; • mitocondria;
Prosesau biolegol	• renal system process; • activation-induced cell death of T cells; • tumor necrosis factor-mediated signaling pathway; • T cell homeostasis; • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; • cellular response to mechanical stimulus; • Rhythm circadaidd; • apoptotic signaling pathway; • positive regulation of extrinsic apoptotic signaling pathway; • regulation of extrinsic apoptotic signaling pathway via death domain receptors; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • GO:0097285 apoptotic process; • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • spleen development; • negative thymic T cell selection; • regulation of lymphocyte differentiation; • necroptotic signaling pathway; • motor neuron apoptotic process; • inflammatory response; • regulation of myeloid cell differentiation; • protein homooligomerization; • response to toxic substance; • B cell mediated immunity; • neuron apoptotic process; • positive regulation of protein homooligomerization; • cellular response to lithium ion; • positive regulation of lymphocyte apoptotic process; • negative regulation of apoptotic process; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • gene expression; • cellular response to hyperoxia; • negative regulation of B cell activation; • response to glucocorticoid; • extrinsic apoptotic signaling pathway in absence of ligand; • inflammatory cell apoptotic process; • immunoglobulin production; • GO:0072468 signal transduction; • hepatocyte apoptotic process; • response to lipopolysaccharide; • extrinsic apoptotic signaling pathway; • regulation of apoptotic process; • positive regulation of apoptotic process; • regulation of cell population proliferation; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • multicellular organism development; • extrinsic apoptotic signaling pathway via death domain receptors; • positive regulation of protein phosphorylation; • regulation of stress-activated MAPK cascade; • cellular response to amino acid starvation; • Fas signaling pathway; • positive regulation of apoptotic signaling pathway; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • GO:0034622 protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologau
	355
	n/a
	ENSG00000026103
	n/a
	P25445
	n/a
NM_000043; NM_152871; NM_152872; NM_152873; NM_152874;
	NM_152875; NM_152876; NM_152877; NM_001320619
	n/a
	NP_000034; NP_001307548; NP_690610; NP_690611
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FAS yw FAS a elwir hefyd yn Fas cell surface death receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q23.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FAS.

APT1
CD95
FAS1
APO-1
FASTM
ALPS1A
TNFRSF6

Llyfryddiaeth

"High Expression of Fas/CD95 on CD4+ Circulating T Cells: An Exclusion Criterion in the Diagnosis of Mycosis Fungoides?". Acta Derm Venereol. 2017. PMID 28206666.
"Combined evaluation of the FAS cell surface death receptor and CD8+ tumor infiltrating lymphocytes as a prognostic biomarker in breast cancer. ". Oncotarget. 2017. PMID 28121628.
"Rare splicing defects of FAS underly severe recessive autoimmune lymphoproliferative syndrome. ". Clin Immunol. 2017. PMID 28668589.
"CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage. ". Cell Death Dis. 2017. PMID 28300842.
"FAS c.-671A>G polymorphism and cervical cancer risk: a case-control study and meta-analysis.". Cancer Genet. 2017. PMID 28279307.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FAS - Cronfa NCBI

[1]

[2]