FBXW7

FBXW7
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2OVP, 2OVQ, 2OVR, 5IBK
Dynodwyr
Cyfenwau	FBXW7, AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4, F-box and WD repeat domain containing 7
Dynodwyr allanol	OMIM: 606278 HomoloGene: 117451 GeneCards: FBXW7
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein-macromolecule adaptor activity; • GO:0001948, GO:0016582 protein binding; • ubiquitin-protein transferase activator activity; • identical protein binding; • ubiquitin protein ligase binding; • cyclin binding; • phosphothreonine residue binding; • GO:0050372 ubiquitin-protein transferase activity; • ubiquitin binding;
Cydrannau o'r gell	• cytoplasm; • Parkin-FBXW7-Cul1 ubiquitin ligase complex; • SCF ubiquitin ligase complex; • nucleoplasm; • nucleolus; • cnewyllyn cell; • cytosol; • mitocondria; • Reticwlwm endoplasmig; • Golgi apparatus; • perinuclear region of cytoplasm;
Prosesau biolegol	• positive regulation of epidermal growth factor-activated receptor activity; • positive regulation of protein targeting to mitochondrion; • negative regulation of SREBP signaling pathway; • cellular response to UV; • negative regulation of triglyceride biosynthetic process; • protein stabilization; • negative regulation of hepatocyte proliferation; • sister chromatid cohesion; • cellular response to DNA damage stimulus; • regulation of protein localization; • positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • vasculature development; • regulation of autophagy of mitochondrion; • negative regulation of DNA endoreduplication; • positive regulation of ubiquitin-protein transferase activity; • positive regulation of ubiquitin-dependent protein catabolic process; • protein ubiquitination; • lipid homeostasis; • positive regulation of ERK1 and ERK2 cascade; • regulation of cell cycle G1/S phase transition; • regulation of lipid storage; • GO:0022415 viral process; • positive regulation of proteasomal protein catabolic process; • positive regulation of protein ubiquitination; • negative regulation of Notch signaling pathway; • protein polyubiquitination; • post-translational protein modification; • negative regulation of osteoclast development; • vasculogenesis; • Notch signaling pathway; • negative regulation of gene expression; • ubiquitin recycling; • lung development; • protein destabilization; • proteasome-mediated ubiquitin-dependent protein catabolic process; • regulation of cell migration involved in sprouting angiogenesis; • negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; • regulation of circadian rhythm; • proses rythmig;
	Sources:Amigo / QuickGO
Orthologau
	55294
	n/a
	ENSG00000109670
	n/a
	Q969H0
	n/a
	NM_001013415; NM_001257069; NM_018315; NM_033632; NM_001349798
	n/a
	NP_001013433; NP_001243998; NP_060785; NP_361014; NP_001336727
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FBXW7 yw FBXW7 a elwir hefyd yn F-box and WD repeat domain containing 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q31.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FBXW7.

AGO
CDC4
FBW6
FBW7
hAgo
FBX30
FBXW6
SEL10
hCdc4
FBXO30
SEL-10

Llyfryddiaeth

"miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7. ". Oncol Rep. 2016. PMID 27350307.
"Loss of FBXW7 is related to the susceptibility and poor prognosis of cervical squamous carcinoma. ". Biomarkers. 2016. PMID 26954701.
"FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study. ". Tumour Biol. 2017. PMID 29072128.
"Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis. ". J Natl Cancer Inst. 2018. PMID 28903484.
"FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors.". Cancer Sci. 2016. PMID 27486687.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FBXW7 - Cronfa NCBI

[1]

[2]