FCGR2A

FCGR2A
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1FCG, 1H9V, 3D5O, 3RY4, 3RY5, 3RY6
Dynodwyr
Cyfenwau	FCGR2A, CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2, Fc fragment of IgG receptor IIa, FcgammaRIIa, Fc gamma receptor IIa
Dynodwyr allanol	OMIM: 146790 HomoloGene: 47936 GeneCards: FCGR2A
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • IgG binding;
Cydrannau o'r gell	• integral component of membrane; • Cellbilen; • bilen; • secretory granule membrane; • Cellfur;
Prosesau biolegol	• Fc-gamma receptor signaling pathway involved in phagocytosis; • immune system process; • neutrophil degranulation; • cell adhesion;
	Sources:Amigo / QuickGO
Orthologau
	2212
	n/a
	ENSG00000143226
	n/a
	P12318
	n/a
	NM_001136219; NM_021642; NM_001375296; NM_001375297
	n/a
	NP_001129691; NP_067674; NP_001362225; NP_001362226
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FCGR2A yw FCGR2A a elwir hefyd yn Low affinity immunoglobulin gamma Fc region receptor II-a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q23.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FCGR2A.

CD32
FCG2
FcGR
CD32A
CDw32
FCGR2
IGFR2
FCGR2A1

Llyfryddiaeth

"Neutrophil FcÎ³RIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases. ". J Clin Invest. 2017. PMID 28891817.
"Male-specific association of the FCGR2A His167Arg polymorphism with Kawasaki disease. ". PLoS One. 2017. PMID 28886140.
"CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses. ". Nature. 2017. PMID 28297712.
"FcÎ³RIIa-H131R variant is associated with inferior response in diffuse large B cell lymphoma: A meta-analysis of genetic risk. ". J BUON. 2016. PMID 28039707.
"[Analysis of single nucleotide polymorphisms and haplotypes of FCGR2A gene among patients with ulcerative colitis].". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016. PMID 27984611.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FCGR2A - Cronfa NCBI

[1]

[2]