FEN1

FEN1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1U7B, 1UL1, 3Q8K, 3Q8L, 3Q8M, 3UVU, 5E0V
Dynodwyr
Cyfenwau	FEN1, Flap endonuclease 1, flap structure-specific endonuclease 1, FEN-1, MF1, RAD2
Dynodwyr allanol	OMIM: 600393 HomoloGene: 3034 GeneCards: FEN1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• metal ion binding; • RNA-DNA hybrid ribonuclease activity; • hydrolase activity, acting on ester bonds; • nuclease activity; • hydrolase activity; • double-stranded DNA binding; • catalytic activity; • damaged DNA binding; • double-stranded DNA exodeoxyribonuclease activity; • GO:0001948, GO:0016582 protein binding; • DNA binding; • endonuclease activity; • exonuclease activity; • 5'-3' exonuclease activity; • 5'-flap endonuclease activity; • flap endonuclease activity; • magnesium ion binding; • manganese ion binding;
Cydrannau o'r gell	• mitocondria; • cnewyllyn cell; • bilen; • nucleoplasm; • nucleolus; • GO:0009327 protein-containing complex;
Prosesau biolegol	• double-strand break repair via homologous recombination; • double-strand break repair; • Cof; • cellular response to DNA damage stimulus; • UV protection; • DNA replication; • GO:0100026 DNA repair; • RNA phosphodiester bond hydrolysis, endonucleolytic; • DNA replication, removal of RNA primer; • positive regulation of sister chromatid cohesion; • nucleic acid phosphodiester bond hydrolysis; • telomere maintenance via semi-conservative replication; • base-excision repair; • apoptotic DNA fragmentation; • retina development in camera-type eye;
	Sources:Amigo / QuickGO
Orthologau
	2237
	n/a
	ENSG00000168496
	n/a
	P39748
	n/a
	NM_004111
	n/a
	NP_004102
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FEN1 yw FEN1 a elwir hefyd yn Flap structure-specific endonuclease 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q12.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FEN1.

MF1
RAD2
FEN-1

Llyfryddiaeth

"The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation. ". Oncogene. 2017. PMID 27270424.
"DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction. ". J Biol Chem. 2016. PMID 26884332.
"Flap endonuclease 1 silencing is associated with increasing the cisplatin sensitivity of SGCâ€‘7901 gastric cancer cells. ". Mol Med Rep. 2016. PMID 26718738.
"The Association of Flap Endonuclease 1 Genotypes with the Risk of Childhood Leukemia. ". Cancer Genomics Proteomics. 2016. PMID 26708601.
"Variants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in China.". Sci Rep. 2015. PMID 26668074.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FEN1 - Cronfa NCBI

[1]

[2]