FKBP5

FKBP5
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1KT0, 3O5D, 3O5E, 3O5F, 3O5G, 3O5I, 3O5J, 3O5K, 3O5L, 3O5M, 3O5O, 3O5P, 3O5Q, 3O5R, 4DRH, 4DRI, 4DRK, 4DRM, 4DRN, 4DRO, 4DRP, 4DRQ, 4JFI, 4JFJ, 4JFK, 4JFL, 4JFM, 4R0X, 4TW6, 4TW7, 4TX0, 4W9O, 4W9P, 4W9Q, 5DIT, 5DIU, 5BXJ, 5DIV
Dynodwyr
Cyfenwau	FKBP5, AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10, FK506 binding protein 5, FKBP prolyl isomerase 5
Dynodwyr allanol	OMIM: 602623 HomoloGene: 3038 GeneCards: FKBP5
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• isomerase activity; • GO:0001948, GO:0016582 protein binding; • heat shock protein binding; • peptidyl-prolyl cis-trans isomerase activity; • FK506 binding;
Cydrannau o'r gell	• extracellular exosome; • bilen; • cnewyllyn cell; • nucleoplasm; • cytoplasm; • cytosol;
Prosesau biolegol	• protein peptidyl-prolyl isomerization; • chaperone-mediated protein folding; • protein folding; • response to bacterium;
	Sources:Amigo / QuickGO
Orthologau
	2289
	n/a
	ENSG00000096060
	n/a
	Q13451
	n/a
	NM_004117; NM_001145775; NM_001145776; NM_001145777
	n/a
	NP_001139247; NP_001139248; NP_001139249; NP_004108
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FKBP5 yw FKBP5 a elwir hefyd yn FK506 binding protein 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FKBP5.

P54
AIG6
FKBP51
FKBP54
PPIase
Ptg-10

Llyfryddiaeth

"Silencing of FKBP51 alleviates the mechanical pain threshold, inhibits DRG inflammatory factors and pain mediators through the NF-kappaB signaling pathway. ". Gene. 2017. PMID 28629826.
"Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation. ". Dev Psychopathol. 2017. PMID 28401840.
"FKBP5 genotype and early life stress exposure predict neurobehavioral outcomes for preterm infants. ". Dev Psychobiol. 2017. PMID 28247564.
"FKBP51 Immunohistochemical Expression: A New Prognostic Biomarker for OSCC?". Int J Mol Sci. 2017. PMID 28218707.
"FKBP51 regulates cell motility and invasion via RhoA signaling.". Cancer Sci. 2017. PMID 28032931.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FKBP5 - Cronfa NCBI

[1]

[2]