FNTB

FNTB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1JCQ, 1LD7, 1LD8, 1MZC, 1S63, 1SA4, 1TN6, 2F0Y, 2H6F, 2H6G, 2H6H, 2H6I, 2IEJ, 3E37
Dynodwyr
Cyfenwau	FNTB, FPTB, farnesyltransferase, CAAX box, beta
Dynodwyr allanol	OMIM: 134636 HomoloGene: 1535 GeneCards: FNTB
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• metal ion binding; • transferase activity; • prenyltransferase activity; • catalytic activity; • protein farnesyltransferase activity; • GO:0001948, GO:0016582 protein binding; • farnesyltranstransferase activity; • zinc ion binding; • isoprenoid binding; • peptide binding;
Cydrannau o'r gell	• cytosol; • protein farnesyltransferase complex; • microtubule associated complex; • GO:0009327 protein-containing complex;
Prosesau biolegol	• protein farnesylation; • positive regulation of cell population proliferation; • negative regulation of cell population proliferation; • response to inorganic substance; • GO:1904578 response to organic cyclic compound; • response to cytokine; • wound healing; • positive regulation of cell cycle; • positive regulation of fibroblast proliferation; • positive regulation of nitric-oxide synthase biosynthetic process; • protein prenylation; • regulation of fibroblast proliferation; • regulation of rhodopsin mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	2342
	n/a
	n/a
	n/a
	P49356
	n/a
	NM_002028
	n/a
	NP_002019; NP_001189487; NP_001189488
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FNTB yw FNTB a elwir hefyd yn Farnesyltransferase, CAAX box, beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q23.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FNTB.

FPTB

Llyfryddiaeth

"Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells. ". Neurosci Lett. 2013. PMID 23643986.
"Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways. ". J Biol Chem. 2012. PMID 22992747.
"Expression of farnesyltransferase in primary liver cancer. ". Chin Med J (Engl). 2012. PMID 22882915.
"Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. ". Cancer Res. 2001. PMID 11751396.
"Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.". J Med Chem. 2003. PMID 12825937.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FNTB - Cronfa NCBI

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[2]