FSHR

FSHR
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1XWD, 4AY9, 4MQW
Dynodwyr
Cyfenwau	FSHR, FSHR1, FSHRO, LGR1, ODG1, follicle stimulating hormone receptor
Dynodwyr allanol	OMIM: 136435 HomoloGene: 117 GeneCards: FSHR
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• G protein-coupled peptide receptor activity; • G protein-coupled receptor activity; • signal transducer activity; • protein-hormone receptor activity; • GO:0001948, GO:0016582 protein binding; • follicle-stimulating hormone receptor activity;
Cydrannau o'r gell	• integral component of membrane; • bilen; • integral component of plasma membrane; • Cellbilen; • intracellular anatomical structure; • receptor complex;
Prosesau biolegol	• G protein-coupled receptor signaling pathway; • male gonad development; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • female gamete generation; • primary ovarian follicle growth; • regulation of protein kinase A signaling; • female gonad development; • activation of adenylate cyclase activity; • regulation of osteoclast differentiation; • spermatogenesis; • hormone-mediated signaling pathway; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of phosphatidylinositol 3-kinase signaling; • gonad development; • GO:0072468 signal transduction; • positive regulation of adenylate cyclase activity; • cellular response to follicle-stimulating hormone stimulus; • follicle-stimulating hormone signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	2492
	n/a
	ENSG00000170820
	n/a
	P23945
	n/a
	NM_000145; NM_181446
	n/a
	NP_000136; NP_852111
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FSHR yw FSHR a elwir hefyd yn Follicle stimulating hormone receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2p16.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FSHR.

LGR1
ODG1
FSHR1
FSHRO

Llyfryddiaeth

"A novel homozygous mutation in the FSHR gene is causative for primary ovarian insufficiency. ". Fertil Steril. 2017. PMID 29157895.
"[Study of two Chinese families affected with resistant ovarian syndrome resulted from novel mutations of FSHR gene]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017. PMID 28397217.
"Functional characterization of two naturally occurring mutations V221G and T449N in the follicle stimulating hormone receptor. ". Mol Cell Endocrinol. 2017. PMID 27889471.
"The carriers of the A/G-G/G allelic combination of the c.2039 A>G and c.-29 G>A FSH receptor polymorphisms retrieve the highest number of oocytes in IVF/ICSI cycles. ". J Assist Reprod Genet. 2017. PMID 27817039.
"Association of a promoter polymorphism in FSHR with ovarian reserve and response to ovarian stimulation in women undergoing assisted reproductive treatment.". Reprod Biomed Online. 2016. PMID 27448492.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FSHR - Cronfa NCBI

[1]

[2]