FTL

FTL
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2FFX, 2FG4, 2FG8, 3KXU
Dynodwyr
Cyfenwau	FTL, LFTD, NBIA3, ferritin, light polypeptide, ferritin light chain
Dynodwyr allanol	OMIM: 134790 HomoloGene: 79330 GeneCards: FTL
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• iron ion binding; • GO:0001948, GO:0016582 protein binding; • ferric iron binding; • metal ion binding; • identical protein binding; • ferroxidase activity; • ferrous iron binding;
Cydrannau o'r gell	• cytosol; • extracellular exosome; • intracellular ferritin complex; • bilen; • extracellular region; • azurophil granule lumen; • autolysosome; • cytoplasm;
Prosesau biolegol	• iron ion homeostasis; • iron ion transport; • cellular iron ion homeostasis; • intracellular sequestering of iron ion; • neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologau
	2512
	n/a
	ENSG00000087086
	n/a
	P02792
	n/a
	NM_000146
	n/a
	NP_000137
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FTL yw FTL a elwir hefyd yn Ferritin light chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.33.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FTL.

LFTD
NBIA3

Llyfryddiaeth

"Impact of non-transferrin-bound iron (NTBI) in comparison to serum ferritin on outcome after allogeneic stem cell transplantation (ASCT). ". Ann Hematol. 2017. PMID 28585071.
"Hepatitis E virus ORF1 encoded macro domain protein interacts with light chain subunit of human ferritin and inhibits its secretion. ". Mol Cell Biochem. 2016. PMID 27170377.
"Ferritin light chain gene mutation in a large Australian family with hereditary hyperferritinemia-cataract syndrome. ". Ophthalmic Genet. 2017. PMID 27096259.
"Relationships between typical histopathological hallmarks and the ferritin in the hippocampus from patients with Alzheimer's disease. ". Acta Neurobiol Exp (Wars). 2015. PMID 26994418.
"Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway.". PLoS One. 2016. PMID 26871431.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FTL - Cronfa NCBI

[1]

[2]