FYN

FYN
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1A0N, 1AOT, 1AOU, 1AVZ, 1AZG, 1EFN, 1FYN, 1G83, 1M27, 1NYF, 1NYG, 1SHF, 1ZBJ, 2DQ7, 3H0F, 3H0H, 3H0I, 3UA6, 3UA7, 4D8D, 4EIK, 2MQI, 2MRJ, 2MRK, 4U17, 4U1P, 4ZNX
Dynodwyr
Cyfenwau	FYN, SLK, SYN, p59-FYN proto-oncogene, Src family tyrosine kinase
Dynodwyr allanol	OMIM: 137025 HomoloGene: 48068 GeneCards: FYN
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• CD4 receptor binding; • transmembrane transporter binding; • GO:0032403 protein-containing complex binding; • GO:0001948, GO:0016582 protein binding; • CD8 receptor binding; • kinase activity; • tubulin binding; • signaling receptor binding; • ATP binding; • protein kinase activity; • metal ion binding; • peptide hormone receptor binding; • T cell receptor binding; • transferase activity; • ephrin receptor binding; • nucleotide binding; • growth factor receptor binding; • phosphatidylinositol 3-kinase binding; • G protein-coupled receptor binding; • non-membrane spanning protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • protein tyrosine kinase activity; • enzyme binding; • identical protein binding; • signal transducer activity; • type 5 metabotropic glutamate receptor binding; • alpha-tubulin binding; • tau protein binding; • tau-protein kinase activity; • disordered domain specific binding;
Cydrannau o'r gell	• cytoplasm; • bilen; • extrinsic component of cytoplasmic side of plasma membrane; • mitocondria; • cnewyllyn cell; • membrane raft; • intracellular membrane-bounded organelle; • Microffilament; • cyrion cell; • endosome; • Cellbilen; • cytosol; • GO:0097483, GO:0097481 postsynaptic density; • dendrite; • cell body; • perinuclear region of cytoplasm; • perinuclear endoplasmic reticulum; • glial cell projection; • Schaffer collateral - CA1 synapse; • glutamatergic synapse; • postsynaptic density, intracellular component;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • adaptive immune response; • learning; • platelet activation; • cell surface receptor signaling pathway; • vascular endothelial growth factor receptor signaling pathway; • feeding behavior; • response to ethanol; • calcium ion transport; • regulation of apoptotic process; • cellular response to transforming growth factor beta stimulus; • Fc-gamma receptor signaling pathway involved in phagocytosis; • GO:1903363 negative regulation of protein catabolic process; • transmembrane receptor protein tyrosine kinase signaling pathway; • stimulatory C-type lectin receptor signaling pathway; • negative regulation of gene expression; • protein autophosphorylation; • T cell activation; • detection of mechanical stimulus involved in sensory perception of pain; • cell differentiation; • dendrite morphogenesis; • phosphorylation; • immune system process; • neuron migration; • cellular response to platelet-derived growth factor stimulus; • regulation of cell shape; • peptidyl-tyrosine autophosphorylation; • phosphatidylinositol-mediated signaling; • leukocyte migration; • positive regulation of protein localization to nucleus; • GO:0007243 intracellular signal transduction; • activated T cell proliferation; • ephrin receptor signaling pathway; • cellular response to growth factor stimulus; • T cell costimulation; • blood coagulation; • GO:0019049, GO:0030683 mitigation of host defenses by virus; • MAPK cascade; • axon guidance; • multicellular organism development; • negative regulation of protein ubiquitination; • cellular response to peptide hormone stimulus; • regulation of cell population proliferation; • positive regulation of neuron projection development; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • forebrain development; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • T cell receptor signaling pathway; • cell migration; • GO:0022415 viral process; • innate immune response; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • phosphatidylinositol phosphate biosynthetic process; • regulation of phosphatidylinositol 3-kinase signaling; • protein phosphorylation; • central nervous system development; • regulation of peptidyl-tyrosine phosphorylation; • positive regulation of protein targeting to membrane; • positive regulation of neuron death; • negative regulation of dendritic spine maintenance; • response to amyloid-beta; • regulation of calcium ion import across plasma membrane; • response to singlet oxygen; • heart process; • negative regulation of hydrogen peroxide biosynthetic process; • cytokine-mediated signaling pathway; • positive regulation of tyrosine phosphorylation of STAT protein; • response to hydrogen peroxide; • modulation of chemical synaptic transmission; • positive regulation of protein kinase B signaling; • dendritic spine maintenance; • regulation of glutamate receptor signaling pathway; • negative regulation of oxidative stress-induced cell death; • positive regulation of non-membrane spanning protein tyrosine kinase activity; • cellular response to L-glutamate; • cellular response to glycine; • positive regulation of protein localization to membrane; • positive regulation of cysteine-type endopeptidase activity; • cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologau
	2534
	n/a
	ENSG00000010810
	n/a
	P06241
	n/a
	NM_001242779; NM_002037; NM_153047; NM_153048; NM_001370529
	n/a
	NP_002028; NP_694592; NP_694593; NP_001357458
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FYN yw FYN a elwir hefyd yn FYN proto-oncogene, Src family tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q21.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FYN.

SLK
SYN
p59-FYN

Llyfryddiaeth

"Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease. ". Neurobiol Aging. 2017. PMID 28033507.
"Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. ". Structure. 2016. PMID 27692963.
"FYN promotes breast cancer progression through epithelial-mesenchymal transition. ". Oncol Rep. 2016. PMID 27349276.
"SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer. ". Oncotarget. 2015. PMID 26624980.
"An isoform-specific role of FynT tyrosine kinase in Alzheimer's disease.". J Neurochem. 2016. PMID 26561212.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FYN - Cronfa NCBI

[1]

[2]