GADD45A

GADD45A
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2KG4
Dynodwyr
Cyfenwau	GADD45A, DDIT1, GADD45, growth arrest and DNA damage inducible alpha
Dynodwyr allanol	OMIM: 126335 HomoloGene: 1449 GeneCards: GADD45A
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • kinase binding; • protein homodimerization activity; • protein heterodimerization activity; • protein N-terminus binding; • RNA polymerase II core promoter sequence-specific DNA binding;
Cydrannau o'r gell	• cytoplasm; • cnewyllyn cell; • nucleoplasm; • nuclear speck;
Prosesau biolegol	• GO:0097285 apoptotic process; • centrosome cycle; • regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of protein kinase activity; • signal transduction in response to DNA damage; • response to stress; • positive regulation of JNK cascade; • regulation of cell cycle; • cellular response to DNA damage stimulus; • cellular response to mechanical stimulus; • positive regulation of reactive oxygen species metabolic process; • positive regulation of apoptotic process; • cellular response to ionizing radiation; • cell cycle; • GO:0100026 DNA repair; • positive regulation of p38MAPK cascade; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologau
	1647
	n/a
	ENSG00000116717
	n/a
	P24522
	n/a
	NM_001924; NM_001199741; NM_001199742
	n/a
	NP_001186670; NP_001186671; NP_001915
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GADD45A yw GADD45A a elwir hefyd yn Growth arrest and DNA damage inducible alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p31.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GADD45A.

DDIT1
GADD45

Llyfryddiaeth

"GADD45α is involved in the apoptosis of lymphocytes induced by riboflavin and ultraviolet light. ". Transfusion. 2017. PMID 27905125.
"A Protective Mechanism of Visible Red Light in Normal Human Dermal Fibroblasts: Enhancement of GADD45A-Mediated DNA Repair Activity. ". J Invest Dermatol. 2017. PMID 27729279.
"GADD45 proteins inhibit HIV-1 replication through specific suppression of HIV-1 transcription. ". Virology. 2016. PMID 26994425.
"The GADD45A (1506T>C) Polymorphism Is Associated with Ovarian Cancer Susceptibility and Prognosis. ". PLoS One. 2015. PMID 26422378.
"Serum GADD45a methylation is a useful biomarker to distinguish benign vs malignant prostate disease.". Br J Cancer. 2015. PMID 26171936.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GADD45A - Cronfa NCBI

[1]

[2]