GBP1

GBP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1DG3, 1F5N, 2B8W, 2B92, 2BC9, 2D4H
Dynodwyr
Cyfenwau	GBP1, guanylate binding protein 1
Dynodwyr allanol	OMIM: 600411 HomoloGene: 133759 GeneCards: GBP1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • Hsp90 protein binding; • spectrin binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • enzyme binding; • actin binding; • hydrolase activity; • GO:0019974 cytokine binding; • GO:0006184 GTPase activity; • GTP binding; • GDP binding; • protein homodimerization activity;
Cydrannau o'r gell	• cytosol; • bilen; • Golgi membrane; • Cellbilen; • extracellular region; • cytoplasm; • Golgi apparatus; • vesicle membrane; • actin cytoskeleton; • GO:0016023 cytoplasmic vesicle;
Prosesau biolegol	• immune system process; • interferon-gamma-mediated signaling pathway; • negative regulation of T cell receptor signaling pathway; • negative regulation of protein localization to plasma membrane; • defense response to virus; • regulation of calcium-mediated signaling; • negative regulation of ERK1 and ERK2 cascade; • negative regulation of substrate adhesion-dependent cell spreading; • regulation of protein localization to plasma membrane; • protein homooligomerization; • cellular response to interferon-gamma; • cellular response to interleukin-1; • cellular response to tumor necrosis factor; • protein localization to vacuole;
	Sources:Amigo / QuickGO
Orthologau
	2633
	n/a
	ENSG00000117228
	n/a
	P32455
	n/a
	NM_002053
	n/a
	NP_002044
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GBP1 yw GBP1 a elwir hefyd yn Guanylate binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p22.2.^[2]

Llyfryddiaeth

"Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel. ". Biochem Biophys Res Commun. 2016. PMID 27590579.
"Tetrameric assembly of hGBP1 is crucial for both stimulated GMP formation and antiviral activity. ". Biochem J. 2016. PMID 27071416.
"Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii. ". Cell Microbiol. 2016. PMID 26874079.
"Guanylate-binding protein 1 (GBP1) promotes lymph node metastasis in human esophageal squamous cell carcinoma. ". Discov Med. 2015. PMID 26760981.
"Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.". Cancer Sci. 2014. PMID 25098609.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GBP1 - Cronfa NCBI

[1]

[2]