GDNF

GDNF
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2V5E, 3FUB, 4UX8
Dynodwyr
Cyfenwau	GDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor, ATF
Dynodwyr allanol	OMIM: 600837 HomoloGene: 433 GeneCards: GDNF
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • GO:0001948, GO:0016582 protein binding; • growth factor activity; • signaling receptor binding; • chemoattractant activity involved in axon guidance;
Cydrannau o'r gell	• extracellular region; • intracellular anatomical structure; • extracellular space;
Prosesau biolegol	• peristalsis; • ureteric bud development; • regulation of dopamine uptake involved in synaptic transmission; • peripheral nervous system development; • sympathetic nervous system development; • organ induction; • adult locomotory behavior; • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; • regulation of stem cell differentiation; • regulation of morphogenesis of a branching structure; • mesenchymal to epithelial transition involved in metanephros morphogenesis; • negative regulation of apoptotic process; • nervous system development; • positive regulation of monooxygenase activity; • enteric nervous system development; • mRNA stabilization; • branching involved in ureteric bud morphogenesis; • postganglionic parasympathetic fiber development; • positive regulation of dopamine secretion; • neural crest cell migration; • postsynaptic membrane organization; • positive regulation of cell population proliferation; • positive regulation of cell differentiation; • positive regulation of ureteric bud formation; • ureteric bud formation; • regulation of gene expression; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • metanephros development; • neuron projection development; • GO:0072468 signal transduction; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • MAPK cascade; • axon guidance; • GO:1904089 negative regulation of neuron apoptotic process; • positive regulation of branching involved in ureteric bud morphogenesis; • regulation of signaling receptor activity; • dorsal spinal cord development; • embryonic organ development; • chemoattraction of axon; • commissural neuron axon guidance; • regulation of semaphorin-plexin signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	2668
	n/a
	ENSG00000168621
	n/a
	P39905
	n/a
NM_000514; NM_001190468; NM_001190469; NM_001278098; NM_199231;
	NM_199234
	n/a
	NP_000505; NP_001177397; NP_001177398; NP_001265027; NP_954701
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GDNF yw GDNF a elwir hefyd yn Glial cell derived neurotrophic factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5p13.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GDNF.

ATF
ATF1
ATF2
HSCR3
HFB1-GDNF

Llyfryddiaeth

"Association between smoking behaviour and genetic variants of glial cell line-derived neurotrophic factor. ". J Genet. 2016. PMID 27994179.
"Concentration of Glial Cell Line-Derived Neurotrophic Factor Positively Correlates with Symptoms in Functional Dyspepsia. ". Dig Dis Sci. 2016. PMID 27718082.
"Relationship Between Chronic Tinnitus and Glial Cell Line-Derived Neurotrophic Factor Gene rs3812047, rs1110149, and rs884344 Polymorphisms in a Turkish Population. ". Biochem Genet. 2016. PMID 27180191.
"Immunohistochemical Analysis of GDNF and Its Cognate Receptor GFRα-1 Protein Expression in Vitiliginous Skin Lesions. ". J Cutan Med Surg. 2016. PMID 26337382.
"An Epigenetic Mechanism of High Gdnf Transcription in Glioma Cells Revealed by Specific Sequence Methylation.". Mol Neurobiol. 2016. PMID 26232065.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GDNF - Cronfa NCBI

[1]

[2]