GEM

GEM
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CJW, 2G3Y, 2HT6
Dynodwyr
Cyfenwau	GEM, KIR, GTP binding protein overexpressed in skeletal muscle
Dynodwyr allanol	OMIM: 600164 HomoloGene: 38024 GeneCards: GEM
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • GTP binding; • GO:0001948, GO:0016582 protein binding; • magnesium ion binding; • calmodulin binding; • GDP binding; • GO:0006184 GTPase activity; • calcium channel regulator activity;
Cydrannau o'r gell	• spindle midzone; • cytoplasmic side of plasma membrane; • Cellbilen; • midbody; • mitotic spindle; • cnewyllyn cell; • bilen;
Prosesau biolegol	• cell surface receptor signaling pathway; • metaphase plate congression; • GO:0051312, GO:0007083 chromosome organization; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • GO:0072468 signal transduction; • GO:0007067 Mitosis; • negative regulation of high voltage-gated calcium channel activity;
	Sources:Amigo / QuickGO
Orthologau
	2669
	n/a
	ENSG00000164949
	n/a
	P55040
	n/a
	NM_181702; NM_005261
	n/a
	NP_005252; NP_859053
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GEM yw GEM a elwir hefyd yn GTP binding protein overexpressed in skeletal muscle (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q22.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GEM.

KIR

Llyfryddiaeth

"Identification of Gem as a new candidate prognostic marker in hepatocellular carcinoma. ". Pathol Res Pract. 2014. PMID 25155751.
"Gem-induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cell conjugates and viral transmission. ". PLoS Pathog. 2014. PMID 24586148.
"The RGK family: a regulatory tail of small GTP-binding proteins. ". Trends Cell Biol. 2005. PMID 16242932.
"Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interaction. ". Proc Natl Acad Sci U S A. 2010. PMID 20679232.
"Biochemical and structural characterization of the gem GTPase.". J Biol Chem. 2007. PMID 17107948.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GEM - Cronfa NCBI

[1]

[2]