GFRA3

GFRA3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2GH0
Dynodwyr
Cyfenwau	GFRA3, GDNFR3, GDNF family receptor alpha 3
Dynodwyr allanol	OMIM: 605710 HomoloGene: 1146 GeneCards: GFRA3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• signaling receptor binding; • axon guidance receptor activity; • GO:0001948, GO:0016582 protein binding; • signaling receptor activity;
Cydrannau o'r gell	• bilen; • anchored component of membrane; • external side of plasma membrane; • extrinsic component of membrane; • Cellbilen; • cytosol; • receptor complex;
Prosesau biolegol	• neuron development; • neuron migration; • peripheral nervous system development; • sympathetic nervous system development; • GO:0072468 signal transduction; • nervous system development; • MAPK cascade; • axon guidance;
	Sources:Amigo / QuickGO
Orthologau
	2676
	n/a
	ENSG00000146013
	n/a
	O60609
	n/a
	NM_001496
	n/a
	NP_001487
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GFRA3 yw GFRA3 a elwir hefyd yn GDNF family receptor alpha 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q31.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GFRA3.

GDNFR3

Llyfryddiaeth

"GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer. ". BMC Cancer. 2016. PMID 26984265.
"Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease. ". J Med Genet. 2000. PMID 10978357.
"Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3). ". Eur J Biochem. 1998. PMID 9490034.
"Craniopharyngiomas express embryonic stem cell markers (SOX2, OCT4, KLF4, and SOX9) as pituitary stem cells but do not coexpress RET/GFRA3 receptors. ". J Clin Endocrinol Metab. 2012. PMID 22031517.
"Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors.". Structure. 2006. PMID 16765900.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GFRA3 - Cronfa NCBI

[1]

[2]