GGA3

GGA3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1JPL, 1JUQ, 1LF8, 1P4U, 1WR6, 1YD8
Dynodwyr
Cyfenwau	GGA3, golgi associated, gamma adaptin ear containing, ARF binding protein 3
Dynodwyr allanol	OMIM: 606006 HomoloGene: 121703 GeneCards: GGA3
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • ubiquitin binding;
Cydrannau o'r gell	• endosome; • trans-Golgi network; • endosome membrane; • intracellular anatomical structure; • bilen; • clathrin adaptor complex; • Golgi apparatus; • early endosome membrane; • recycling endosome membrane; • early endosome; • recycling endosome;
Prosesau biolegol	• protein transport; • intracellular protein transport; • GO:1903364 positive regulation of protein catabolic process; • vesicle-mediated transport; • protein localization to lysosome; • regulation of protein stability; • protein destabilization; • endocytic recycling; • protein localization to cell surface; • Golgi to plasma membrane protein transport; • negative regulation of amyloid-beta formation;
	Sources:Amigo / QuickGO
Orthologau
	23163
	n/a
	ENSG00000125447
	n/a
	Q9NZ52
	n/a
NM_001172703; NM_001172704; NM_001291641; NM_001291642; NM_014001;
	NM_138619
	n/a
NP_001166174; NP_001166175; NP_001278570; NP_001278571; NP_054720;
	NP_619525
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GGA3 yw GGA3 a elwir hefyd yn Golgi associated, gamma adaptin ear containing, ARF binding protein 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.1.^[2]

Llyfryddiaeth

"GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export. ". Mol Cell Biol. 2016. PMID 26811329.
"GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. ". Mol Biol Cell. 2015. PMID 26446845.
"Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3. ". Traffic. 2016. PMID 26935970.
"Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. ". Neuron. 2007. PMID 17553422.
"Predominant expression of the short form of GGA3 in human cell lines and tissues.". Biochem Biophys Res Commun. 2003. PMID 12810073.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GGA3 - Cronfa NCBI

[1]

[2]