GHR

GHR
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1A22, 1AXI, 1HWG, 1HWH, 1KF9, 2AEW, 3HHR
Dynodwyr
Cyfenwau	GHR, GHBP, GHIP, growth hormone receptor
Dynodwyr allanol	OMIM: 600946 HomoloGene: 134 GeneCards: GHR
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • growth factor binding; • peptide hormone binding; • GO:0001948, GO:0016582 protein binding; • GO:0016518 cytokine receptor activity; • proline-rich region binding; • protein kinase binding; • identical protein binding; • growth hormone receptor activity; • GO:0019974 cytokine binding;
Cydrannau o'r gell	• integral component of membrane; • bilen; • receptor complex; • integral component of plasma membrane; • extracellular region; • cell surface; • growth hormone receptor complex; • extracellular space; • cytosol; • Cellbilen; • cytoplasmic ribonucleoprotein granule; • external side of plasma membrane;
Prosesau biolegol	• insulin-like growth factor receptor signaling pathway; • receptor signaling pathway via JAK-STAT; • growth hormone receptor signaling pathway via JAK-STAT; • response to estradiol; • endocytosis; • allantoin metabolic process; • regulation of multicellular organism growth; • cytokine-mediated signaling pathway; • citrate metabolic process; • receptor internalization; • response to cycloheximide; • 2-oxoglutarate metabolic process; • creatinine metabolic process; • oxaloacetate metabolic process; • fatty acid metabolic process; • succinate metabolic process; • cellular response to hormone stimulus; • growth hormone receptor signaling pathway; • taurine metabolic process; • valine metabolic process; • positive regulation of multicellular organism growth; • positive regulation of peptidyl-tyrosine phosphorylation; • creatine metabolic process; • isoleucine metabolic process; • positive regulation of tyrosine phosphorylation of STAT protein; • activation of Janus kinase activity; • hormone metabolic process; • positive regulation of receptor signaling pathway via JAK-STAT;
	Sources:Amigo / QuickGO
Orthologau
	2690
	n/a
	ENSG00000112964
	n/a
	P10912
	n/a
NM_000163; NM_001242399; NM_001242400; NM_001242401; NM_001242402;
	NM_001242403; NM_001242404; NM_001242405; NM_001242406; NM_001242460; NM_001242461; NM_001242462
	n/a
NP_000154; NP_001229328; NP_001229329; NP_001229330; NP_001229331;
	NP_001229332; NP_001229333; NP_001229334; NP_001229335; NP_001229389; NP_001229391
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GHR yw GHR a elwir hefyd yn Growth hormone receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5p13.1-p12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GHR.

GHBP
GHIP

Llyfryddiaeth

"Computational Investigation of Growth Hormone Receptor Trp169Arg Heterozygous Mutation in a Child With Short Stature. ". J Cell Biochem. 2017. PMID 28523647.
"The impact of the d3-growth hormone receptor (d3-GHR) polymorphism on the therapeutic effect of growth hormone replacement in children with idiopathic growth hormone deficiency in Poland. ". Neuro Endocrinol Lett. 2016. PMID 27857044.
"Growth hormone receptor expression in human gluteal versus abdominal subcutaneous adipose tissue: Association with body shape. ". Obesity (Silver Spring). 2016. PMID 27015877.
"GHR/PRLR Heteromultimer Is Composed of GHR Homodimers and PRLR Homodimers. ". Mol Endocrinol. 2016. PMID 27003442.
"Growth hormone receptor exon 3 isoforms may have no importance in the clinical setting of multiethnic Brazilian acromegaly patients.". Pituitary. 2016. PMID 27001494.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GHR - Cronfa NCBI

[1]

[2]