GLI1

GLI1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2GLI, 4BLB, 4KMD
Dynodwyr
Cyfenwau	GLI1, GLI, GLI family zinc finger 1, PAPA8, PPD1
Dynodwyr allanol	OMIM: 165220 HomoloGene: 3859 GeneCards: GLI1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • microtubule binding; • chromatin binding; • metal ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 protein binding; • nucleic acid binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • cytosol; • cilium; • nucleoplasm; • ciliary base; • ciliary tip; • GO:0035085 axoneme; • cnewyllyn cell;
Prosesau biolegol	• epidermal cell differentiation; • proximal/distal pattern formation; • cell differentiation; • pituitary gland development; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of smoothened signaling pathway; • lung development; • positive regulation of cell migration; • smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; • notochord regression; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of DNA replication; • ventral midline development; • multicellular organism development; • regulation of smoothened signaling pathway; • liver regeneration; • response to wounding; • regulation of osteoblast differentiation; • osteoblast differentiation; • spermatogenesis; • positive regulation of cell population proliferation; • cerebellar cortex morphogenesis; • regulation of hepatocyte proliferation; • canonical Wnt signaling pathway; • smoothened signaling pathway; • dorsal/ventral pattern formation; • negative regulation of canonical Wnt signaling pathway; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • digestive tract morphogenesis; • prostate gland development; • positive regulation of cardiac muscle cell proliferation; • positive regulation of cell cycle G1/S phase transition;
	Sources:Amigo / QuickGO
Orthologau
	2735
	n/a
	ENSG00000111087
	n/a
	P08151
	n/a
	NM_001160045; NM_001167609; NM_005269
	n/a
	NP_001153517; NP_001161081; NP_005260
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GLI1 yw GLI1 a elwir hefyd yn GLI family zinc finger 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GLI1.

GLI

Llyfryddiaeth

"Gli1 is a potential cancer stem cell marker and predicts poor prognosis in ductal breast carcinoma. ". Hum Pathol. 2017. PMID 28965964.
"Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. ". Cancer Lett. 2017. PMID 28965853.
"Role of Hedgehog-Gli1 signaling in the enhanced proliferation and differentiation of MG63 cells enabled by hierarchical micro-/nanotextured topography. ". Int J Nanomedicine. 2017. PMID 28458545.
"Gli1 expression in cancer stem-like cells predicts poor prognosis in patients with lung squamous cell carcinoma. ". Exp Mol Pathol. 2017. PMID 28286162.
"Gli1 Expression in Human Epiretinal Membranes.". Invest Ophthalmol Vis Sci. 2017. PMID 28134963.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GLI1 - Cronfa NCBI

[1]

[2]