GLP1R

GLP1R
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3C59, 3C5T, 3IOL, 4ZGM
Dynodwyr
Cyfenwau	GLP1R, glucagon-like peptide 1 receptor, GLP-1, GLP-1-R, GLP-1R, glucagon like peptide 1 receptor
Dynodwyr allanol	OMIM: 138032 HomoloGene: 1558 GeneCards: GLP1R
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• G protein-coupled peptide receptor activity; • G protein-coupled receptor activity; • signal transducer activity; • GO:0001948, GO:0016582 protein binding; • glucagon receptor activity; • transmembrane signaling receptor activity; • glucagon-like peptide 1 receptor activity; • peptide hormone binding;
Cydrannau o'r gell	• integral component of membrane; • bilen; • Cellbilen; • intracellular anatomical structure; • integral component of plasma membrane;
Prosesau biolegol	• regulation of heart contraction; • regulation of insulin secretion; • positive regulation of cytosolic calcium ion concentration; • cellular response to glucagon stimulus; • activation of adenylate cyclase activity; • cell surface receptor signaling pathway; • positive regulation of blood pressure; • learning or memory; • cAMP-mediated signaling; • GO:0072468 signal transduction; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • G protein-coupled receptor signaling pathway; • response to psychosocial stress;
	Sources:Amigo / QuickGO
Orthologau
	2740
	n/a
	ENSG00000112164
	n/a
	P43220
	n/a
	NM_002062
	n/a
	NP_002053
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GLP1R yw GLP1R a elwir hefyd yn Glucagon like peptide 1 receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GLP1R.

GLP-1
GLP-1R
GLP-1-R

Llyfryddiaeth

"Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor. ". PLoS One. 2017. PMID 28609478.
"Crystal structure of the GLP-1 receptor bound to a peptide agonist. ". Nature. 2017. PMID 28562585.
"Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R). ". J Biol Chem. 2017. PMID 28283573.
"Real-World Glycemic Control from GLP-1RA Therapy with and Without Concurrent Insulin in Patients with Type 2 Diabetes. ". J Manag Care Spec Pharm. 2017. PMID 28230449.
"Immunohistochemical assessment of glucagon-like peptide 1 receptor (GLP-1R) expression in the pancreas of patients with type 2 diabetes.". Diabetes Obes Metab. 2017. PMID 28094469.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GLP1R - Cronfa NCBI

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[2]