GLRX

GLRX
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1B4Q, 1JHB, 4RQR
Dynodwyr
Cyfenwau	GLRX, GRX, GRX1, glutaredoxin
Dynodwyr allanol	OMIM: 600443 HomoloGene: 37566 GeneCards: GLRX
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein-disulfide reductase activity; • electron transfer activity; • glutathione oxidoreductase activity; • protein N-terminus binding; • glutathione disulfide oxidoreductase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • extracellular exosome; • mitocondria; • cnewyllyn cell;
Prosesau biolegol	• positive regulation of sodium ion transmembrane transporter activity; • nucleobase-containing small molecule interconversion; • positive regulation of membrane potential; • protein deglutathionylation; • cell redox homeostasis; • electron transport chain;
	Sources:Amigo / QuickGO
Orthologau
	2745
	n/a
	ENSG00000173221
	n/a
	P35754
	n/a
	NM_002064; NM_001118890; NM_001243658; NM_001243659
	n/a
	NP_001112362; NP_001230587; NP_001230588; NP_002055
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GLRX yw GLRX a elwir hefyd yn Glutaredoxin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q15.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GLRX.

GRX
GRX1

Llyfryddiaeth

"Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes. ". Biochem J. 2017. PMID 28963348.
"Glutaredoxin 1 (GRX1) inhibits oxidative stress and apoptosis of chondrocytes by regulating CREB/HO-1 in osteoarthritis. ". Mol Immunol. 2017. PMID 28843170.
"Determination of glutathione redox potential and pH value in subcellular compartments of malaria parasites. ". Free Radic Biol Med. 2017. PMID 28062360.
"Glutaredoxin Desensitizes Lens to Oxidative Stress by Connecting and Integrating Specific Signaling and Transcriptional Regulation for Antioxidant Response. ". Cell Physiol Biochem. 2016. PMID 27744453.
"Glutaredoxin 1 (Grx1) Protects Human Retinal Pigment Epithelial Cells From Oxidative Damage by Preventing AKT Glutathionylation.". Invest Ophthalmol Vis Sci. 2015. PMID 25788646.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GLRX - Cronfa NCBI

[1]

[2]