GLRX2

GLRX2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CQ9, 2FLS, 2HT9
Dynodwyr
Cyfenwau	GLRX2, CGI-133, GRX2, glutaredoxin 2
Dynodwyr allanol	OMIM: 606820 HomoloGene: 41098 GeneCards: GLRX2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• metal ion binding; • arsenate reductase (glutaredoxin) activity; • electron transfer activity; • glutathione disulfide oxidoreductase activity; • iron-sulfur cluster binding; • protein-disulfide reductase activity; • 2 iron, 2 sulfur cluster binding; • GO:0030508 protein disulfide isomerase activity;
Cydrannau o'r gell	• nucleoplasm; • mitocondria; • mitochondrial matrix; • cnewyllyn cell; • intracellular membrane-bounded organelle; • soma; • dendrite;
Prosesau biolegol	• glutathione metabolic process; • DNA protection; • response to temperature stimulus; • response to redox state; • regulation of signal transduction; • GO:0097285 apoptotic process; • GO:0010260 heneiddio; • GO:0009373 regulation of transcription, DNA-templated; • response to organic substance; • response to hydrogen peroxide; • cell differentiation; • cellular response to superoxide; • cell redox homeostasis; • electron transport chain;
	Sources:Amigo / QuickGO
Orthologau
	51022
	n/a
	ENSG00000023572
	n/a
	Q9NS18
	n/a
	NM_001243399; NM_016066; NM_197962
	n/a
	NP_001230328; NP_057150; NP_932066
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GLRX2 yw GLRX2 a elwir hefyd yn Glutaredoxin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q31.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GLRX2.

GRX2
CGI-133

Llyfryddiaeth

"Two types of human malignant melanoma cell lines revealed by expression patterns of mitochondrial and survival-apoptosis genes: implications for malignant melanoma therapy. ". Mol Cancer Ther. 2009. PMID 19383853.
"Oxidative disassembly of the [2Fe-2S] cluster of human Grx2 and redox regulation in the mitochondria. ". Biochemistry. 2009. PMID 19292455.
"Glutaredoxin 2a, a mitochondrial isoform, plays a protective role in a human cell line under serum deprivation. ". Mol Biol Rep. 2012. PMID 21735102.
"Glutaredoxin 2 prevents H(2)O(2)-induced cell apoptosis by protecting complex I activity in the mitochondria. ". Biochim Biophys Acta. 2010. PMID 20547138.
"In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2.". Chem Biol. 2009. PMID 20064440.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GLRX2 - Cronfa NCBI

[1]

[2]