GNA13

GNA13
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1SHZ, 1ZCB, 3AB3, 3CX6, 3CX7, 3CX8
Dynodwyr
Cyfenwau	GNA13, G13, G protein subunit alpha 13, HG1N
Dynodwyr allanol	OMIM: 604406 HomoloGene: 55976 GeneCards: GNA13
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • G-protein beta/gamma-subunit complex binding; • type 1 angiotensin receptor binding; • GTP binding; • D5 dopamine receptor binding; • signal transducer activity; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • guanyl nucleotide binding; • G protein-coupled receptor binding; • guanyl-nucleotide exchange factor activity; • GO:0006184 GTPase activity;
Cydrannau o'r gell	• bilen; • focal adhesion; • melanosome; • brush border membrane; • heterotrimeric G-protein complex; • extracellular exosome; • cnewyllyn cell; • cytoplasm; • cytosol; • Cellbilen;
Prosesau biolegol	• cell differentiation; • GO:0007243 intracellular signal transduction; • regulation of cell migration; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • positive regulation of cytosolic calcium ion concentration; • small GTPase mediated signal transduction; • in utero embryonic development; • platelet activation; • activation of phospholipase D activity; • Rho protein signal transduction; • angiogenesis; • regulation of cell shape; • branching involved in blood vessel morphogenesis; • GO:0072468 signal transduction; • positive regulation of apoptotic process; • regulation of small GTPase mediated signal transduction; • G protein-coupled receptor signaling pathway; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	10672
	n/a
	ENSG00000120063
	n/a
	Q14344
	n/a
	NM_001282425; NM_006572
	n/a
	NP_001269354; NP_006563
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GNA13 yw GNA13 a elwir hefyd yn G protein subunit alpha 13 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q24.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GNA13.

G13

Llyfryddiaeth

"Distinct regions of Galpha13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs. ". Cell Signal. 2007. PMID 17449226.
"Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics. ". J Proteomics. 2017. PMID 28214564.
"GNA13 as a prognostic factor and mediator of gastric cancer progression. ". Oncotarget. 2016. PMID 26735177.
"Gα13 Switch Region 2 Binds to the Talin Head Domain and Activates αIIbβ3 Integrin in Human Platelets. ". J Biol Chem. 2015. PMID 26292217.
"Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing.". Blood. 2013. PMID 23699601.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GNA13 - Cronfa NCBI

[1]

[2]