GNAI1

GNAI1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1KJY, 1Y3A, 2G83, 2GTP, 2IK8, 2OM2, 2XNS, 3ONW, 3QE0, 3QI2, 3UMR, 3UMS, 4G5Q, 5JS7, 5JS8
Dynodwyr
Cyfenwau	GNAI1, Gi, G protein subunit alpha i1, HG1B, NEDHISB
Dynodwyr allanol	OMIM: 139310 HomoloGene: 74417 GeneCards: GNAI1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GTPase activating protein binding; • nucleotide binding; • G-protein beta/gamma-subunit complex binding; • GDP binding; • G protein-coupled serotonin receptor binding; • signal transducer activity; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • guanyl nucleotide binding; • G protein-coupled receptor binding; • GTP binding; • magnesium ion binding; • GO:0006184 GTPase activity;
Cydrannau o'r gell	• cytoplasm; • centrosome; • bilen; • Cellbilen; • intracellular anatomical structure; • microtubule organizing center; • lysosomal membrane; • midbody; • heterotrimeric G-protein complex; • membrane raft; • extracellular exosome; • Cytosgerbwd; • cnewyllyn cell; • nucleolus; • cell cortex region; • cell cortex; • GO:0009327 protein-containing complex;
Prosesau biolegol	• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • response to peptide hormone; • negative regulation of synaptic transmission; • Cellraniad; • cell cycle; • GO:0072468 signal transduction; • regulation of cAMP-mediated signaling; • cellular response to forskolin; • protein folding; • regulation of mitotic spindle organization; • positive regulation of protein localization to cell cortex; • GO:0015915 transport; • G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	2770
	n/a
	ENSG00000127955
	n/a
	P63096
	n/a
	NM_002069; NM_001256414
	n/a
	NP_001243343; NP_002060
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GNAI1 yw GNAI1 a elwir hefyd yn G protein subunit alpha i1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q21.11.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GNAI1.

Gi

Llyfryddiaeth

"A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor. ". J Biol Chem. 2016. PMID 27462082.
"Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding. ". Proc Natl Acad Sci U S A. 2016. PMID 27298341.
"Probing Gαi1 protein activation at single-amino acid resolution. ". Nat Struct Mol Biol. 2015. PMID 26258638.
"Integration of Fourier Transform Infrared Spectroscopy, Fluorescence Spectroscopy, Steady-state Kinetics and Molecular Dynamics Simulations of Gαi1 Distinguishes between the GTP Hydrolysis and GDP Release Mechanism. ". J Biol Chem. 2015. PMID 25979337.
"Mutation analysis of inhibitory guanine nucleotide binding protein alpha (GNAI) loci in young and familial pituitary adenomas.". PLoS One. 2014. PMID 25291362.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GNAI1 - Cronfa NCBI

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[2]