GP1BA

GP1BA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1GWB, 1M0Z, 1M10, 1OOK, 1P8V, 1P9A, 1QYY, 1SQ0, 1U0N, 2BP3, 3P72, 3PMH, 4C2A, 4C2B, 4CH2, 4CH8, 4MGX, 4YR6
Dynodwyr
Cyfenwau	GP1BA, BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GPIbA, VWDP, GPIbalpha, glycoprotein Ib platelet alpha subunit, glycoprotein Ib platelet subunit alpha
Dynodwyr allanol	OMIM: 606672 HomoloGene: 143 GeneCards: GP1BA
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein kinase inhibitor activity; • thrombin-activated receptor activity; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • bilen; • Cellbilen; • integral component of plasma membrane; • cell surface; • anchored component of external side of plasma membrane; • extracellular exosome; • extracellular space; • GO:0005578 extracellular matrix;
Prosesau biolegol	• blood coagulation, intrinsic pathway; • hemostasis; • fibrinolysis; • negative regulation of protein kinase activity; • cytokine-mediated signaling pathway; • blood coagulation; • platelet activation; • cell surface receptor signaling pathway; • cell adhesion; • GO:0000767 cell morphogenesis; • regulation of blood coagulation; • negative regulation of receptor signaling pathway via JAK-STAT; • thrombin-activated receptor signaling pathway; • platelet aggregation; • regulation of megakaryocyte differentiation;
	Sources:Amigo / QuickGO
Orthologau
	2811
	n/a
	ENSG00000185245
	n/a
	P07359
	n/a
	NM_000173
	n/a
	NP_000164
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GP1BA yw GP1BA a elwir hefyd yn Glycoprotein Ib platelet alpha subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17p13.2.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GP1BA.

BSS
GP1B
VWDP
CD42B
GPIbA
BDPLT1
BDPLT3
DBPLT3
GPIbalpha
CD42b-alpha

Llyfryddiaeth[golygu | golygu cod]

"Inhibiting GPIbα Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged Storage. ". Arterioscler Thromb Vasc Biol. 2016. PMID 27417583.
"Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance. ". J Thromb Haemost. 2016. PMID 26662889.
"[The molecular mechanisms of platelets activation in patients with cerebrovascular disease]. ". Biomed Khim. 2015. PMID 26539867.
"Hemoglobin interaction with GP1bα induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. ". Haematologica. 2015. PMID 26341739.
"Association between polymorphisms of platelet membrane glycoprotein Ibα and risk of coronary heart disease in Han Chinese, Henan, China.". Int J Clin Exp Pathol. 2015. PMID 26191334.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] GP1BA - Cronfa NCBI

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[2]