GRAP2

GRAP2
Dynodwyr
Cyfenwau	GRAP2, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38, GRB2-related adaptor protein 2, GRB2 related adaptor protein 2
Dynodwyr allanol	OMIM: 604518 HomoloGene: 21007 GeneCards: GRAP2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • non-membrane spanning protein tyrosine kinase activity; • signaling receptor binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • endosome; • cnewyllyn cell; • extrinsic component of cytoplasmic side of plasma membrane;
Prosesau biolegol	• Fc-epsilon receptor signaling pathway; • cell-cell signaling; • T cell costimulation; • Ras protein signal transduction; • T cell receptor signaling pathway; • positive regulation of signal transduction; • transmembrane receptor protein tyrosine kinase signaling pathway; • cell migration; • cell differentiation; • peptidyl-tyrosine autophosphorylation; • regulation of cell population proliferation; • innate immune response;
	Sources:Amigo / QuickGO
Orthologau
	9402
	n/a
	ENSG00000100351
	n/a
	O75791
	n/a
	NM_001291824; NM_001291825; NM_001291826; NM_001291828; NM_004810
	n/a
	NP_001278753; NP_001278754; NP_001278755; NP_001278757; NP_004801
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GRAP2 yw GRAP2 a elwir hefyd yn GRB2-related adaptor protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q13.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GRAP2.

P38
GADS
GRID
GRPL
GrbX
Mona
GRB2L
GRBLG
Grf40
GRAP-2

Llyfryddiaeth

"Upstream open reading frames regulate translation of Mona/Gads adapter mRNA in the megakaryocytic lineage. ". Platelets. 2002. PMID 12487779.
"Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters. ". Gene. 2002. PMID 12062812.
"GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells. ". Cell Signal. 2015. PMID 25636200.
"Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma. ". Cancer Lett. 2009. PMID 19027225.
"Grap-2, a novel RET binding protein, is involved in RET mitogenic signaling.". Oncogene. 2003. PMID 12917638.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GRAP2 - Cronfa NCBI

[1]

[2]