GRB10

GRB10
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3HK0, 1NRV
Dynodwyr
Cyfenwau	GRB10, GRB-IR, Grb-10, IRBP, MEG1, RSS, growth factor receptor bound protein 10
Dynodwyr allanol	OMIM: 601523 HomoloGene: 3882 GeneCards: GRB10
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • insulin receptor binding; • identical protein binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • Cellbilen; • GO:0009327 protein-containing complex;
Prosesau biolegol	• response to insulin; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • negative regulation of glucose import; • GO:1903105 negative regulation of insulin receptor signaling pathway; • insulin-like growth factor receptor signaling pathway; • negative regulation of phosphorylation; • positive regulation of phosphorylation; • negative regulation of glycogen biosynthetic process; • GO:0072468 signal transduction; • GO:1901047 insulin receptor signaling pathway; • axon guidance; • negative regulation of Wnt signaling pathway; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologau
	2887
	n/a
	ENSG00000106070
	n/a
	Q13322
	n/a
NM_001001549; NM_001001550; NM_001001555; NM_005311; NM_001350814;
	NM_001350815; NM_001350816; NM_001371008; NM_001371009
	n/a
NP_001001549; NP_001001550; NP_001001555; NP_001337743; NP_001337744;
	NP_001337745; NP_001357937; NP_001357938
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GRB10 yw GRB10 a elwir hefyd yn Growth factor receptor bound protein 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p12.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GRB10.

RSS
IRBP
MEG1
GRB-IR
Grb-10

Llyfryddiaeth

"Placental expression of the insulin receptor binding protein GRB10: Relation to human fetoplacental growth and fetal gender. ". Placenta. 2015. PMID 26390806.
"Association of the intronic polymorphism rs12540874 A>G of the GRB10 gene with high birth weight. ". Early Hum Dev. 2014. PMID 25103788.
"A central role for GRB10 in regulation of islet function in man. ". PLoS Genet. 2014. PMID 24699409.
"Grb10 interacts with Bim L and inhibits apoptosis. ". Mol Biol Rep. 2010. PMID 20174874.
"Association of hGrb10 genetic variations with type 2 diabetes in Caucasian subjects.". Diabetes Care. 2006. PMID 16644667.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GRB10 - Cronfa NCBI

[1]

[2]