GRIN2B

GRIN2B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	5EWM, 5EWL, 5EWJ
Dynodwyr
Cyfenwau	GRIN2B, GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27, glutamate ionotropic receptor NMDA type subunit 2B, NR3, DEE27
Dynodwyr allanol	OMIM: 138252 HomoloGene: 646 GeneCards: GRIN2B
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• zinc ion binding; • glycine binding; • metal ion binding; • ion channel activity; • GO:0001948, GO:0016582 protein binding; • ionotropic glutamate receptor activity; • extracellularly glutamate-gated ion channel activity; • NMDA glutamate receptor activity; • glutamate binding; • glutamate-gated calcium ion channel activity; • amyloid-beta binding; • signaling receptor activity;
Cydrannau o'r gell	• integral component of membrane; • postsynaptic membrane; • bilen; • synapse; • NMDA selective glutamate receptor complex; • cell surface; • cell junction; • neuron projection; • intracellular anatomical structure; • integral component of plasma membrane; • GO:0097483, GO:0097481 postsynaptic density; • Cellbilen; • cytoplasm; • synaptic membrane; • postsynaptic density membrane;
Prosesau biolegol	• glutamate receptor signaling pathway; • ephrin receptor signaling pathway; • cludo ïon; • MAPK cascade; • learning or memory; • response to ethanol; • chemical synaptic transmission; • ionotropic glutamate receptor signaling pathway; • excitatory postsynaptic potential; • regulation of ion transmembrane transport; • GO:0015915 transport; • calcium-mediated signaling; • protein heterotetramerization; • regulation of molecular function; • GO:0060401 calcium ion transmembrane import into cytosol; • multicellular organism development; • brain development; • regulation of synaptic plasticity; • long-term potentiation; • excitatory chemical synaptic transmission; • positive regulation of neuron death; • negative regulation of dendritic spine maintenance; • positive regulation of cysteine-type endopeptidase activity; • regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologau
	2904
	n/a
	ENSG00000273079
	n/a
	Q13224
	n/a
	NM_000834
	n/a
	NP_000825
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GRIN2B yw GRIN2B a elwir hefyd yn Glutamate ionotropic receptor NMDA type subunit 2B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p13.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GRIN2B.

NR3
MRD6
NR2B
hNR3
EIEE27
GluN2B
NMDAR2B

Llyfryddiaeth

"NMDA receptors: linking physiological output to biophysical operation. ". Nat Rev Neurosci. 2017. PMID 28303017.
"Human GRIN2B variants in neurodevelopmental disorders. ". J Pharmacol Sci. 2016. PMID 27818011.
"Further evidence for GRIN2B mutation as the cause of severe epileptic encephalopathy. ". Am J Med Genet A. 2016. PMID 27605359.
"A study of single nucleotide polymorphisms of GRIN2B in schizophrenia from Chinese Han population. ". Neurosci Lett. 2016. PMID 27453061.
"Association of GRIN2B gene polymorphism and Obsessive Compulsive disorder and symptom dimensions: A pilot study.". Psychiatry Res. 2016. PMID 27394963.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GRIN2B - Cronfa NCBI

[1]

[2]