GRM3

GRM3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3SM9, 4XAR, 5CNK, 5CNM
Dynodwyr
Cyfenwau	GRM3, GLUR3, GPRC1C, MGLUR3, mGlu3, glutamate metabotropic receptor 3
Dynodwyr allanol	OMIM: 601115 HomoloGene: 651 GeneCards: GRM3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• glutamate receptor activity; • group II metabotropic glutamate receptor activity; • calcium channel regulator activity; • signal transducer activity; • G protein-coupled receptor activity;
Cydrannau o'r gell	• integral component of membrane; • axon; • neuron projection; • dendritic spine; • postsynaptic membrane; • integral component of plasma membrane; • GO:0097483, GO:0097481 postsynaptic density; • bilen; • Cellbilen; • presynaptic membrane; • glutamatergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
Prosesau biolegol	• negative regulation of adenylate cyclase activity; • GO:0072468 signal transduction; • chemical synaptic transmission; • regulation of synaptic transmission, glutamatergic; • adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; • G protein-coupled glutamate receptor signaling pathway; • G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	2913
	n/a
	ENSG00000198822
	n/a
	Q14832
	n/a
	NM_000840; NM_001363522
	n/a
	NP_000831; NP_001350451
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GRM3 yw GRM3 a elwir hefyd yn Metabotropic glutamate receptor 3 a Glutamate metabotropic receptor 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q21.11-q21.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GRM3.

GLUR3
mGlu3
GPRC1C
MGLUR3

Llyfryddiaeth

"Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis. ". Int J Oncol. 2016. PMID 27431857.
"Evaluation of relationship between GRM3 polymorphisms and cognitive function in schizophrenia of Han Chinese. ". Psychiatry Res. 2015. PMID 26187343.
"Effect of metabotropic glutamate receptor-3 variants on prefrontal brain activity in schizophrenia: An imaging genetics study using multi-channel near-infrared spectroscopy. ". Prog Neuropsychopharmacol Biol Psychiatry. 2015. PMID 25914064.
"mGluR3 promotes proliferation of human embryonic cortical neural progenitor cells by activating ERK1/2 and JNK2 signaling pathway in vitro. ". Cell Mol Biol (Noisy-le-grand). 2014. PMID 25198581.
"Pharmacogenetic associations of the type-3 metabotropic glutamate receptor (GRM3) gene with working memory and clinical symptom response to antipsychotics in first-episode schizophrenia.". Psychopharmacology (Berl). 2015. PMID 25096017.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GRM3 - Cronfa NCBI

[1]

[2]