GSTO1

GSTO1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1EEM, 3LFL, 3VLN, 4IS0
Dynodwyr
Cyfenwau	GSTO1, GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, glutathione S-transferase omega 1
Dynodwyr allanol	OMIM: 605482 HomoloGene: 37971 GeneCards: GSTO1
EC number	1.20.4.2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • glutathione dehydrogenase (ascorbate) activity; • GO:0001948, GO:0016582 protein binding; • methylarsonate reductase activity; • oxidoreductase activity; • glutathione transferase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • extracellular exosome;
Prosesau biolegol	• xenobiotic catabolic process; • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; • negative regulation of ryanodine-sensitive calcium-release channel activity; • positive regulation of ryanodine-sensitive calcium-release channel activity; • methylation; • cellular response to arsenic-containing substance; • positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; • metabolaeth; • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; • glutathione derivative biosynthetic process; • L-ascorbic acid metabolic process; • cellular oxidant detoxification; • glutathione metabolic process; • toxin catabolic process; • interleukin-12-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	9446
	n/a
	ENSG00000148834
	n/a
	P78417; Q5TA02
	n/a
	NM_004832; NM_001191002; NM_001191003
	n/a
	NP_001177931; NP_001177932; NP_004823
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GSTO1 yw GSTO1 a elwir hefyd yn Glutathione S-transferase omega-1 a Glutathione S-transferase omega 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q25.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GSTO1.

P28
SPG-R
GSTO*1-1
GSTTLp28
HEL-S-21

Llyfryddiaeth

"A role for glutathione transferase Omega 1 (GSTO1-1) in the glutathionylation cycle. ". J Biol Chem. 2013. PMID 23888047.
"Association between glutathione S-transferase omega 1 A140D polymorphism in the Turkish population and susceptibility to non-small cell lung cancer. ". Arh Hig Rada Toksikol. 2013. PMID 23819933.
"Genetic polymorphisms in Glutathione S-transferase Omega (GSTO) and cancer risk: a meta-analysis of 20 studies. ". Sci Rep. 2014. PMID 25300926.
"Identification of glutathione S-transferase omega 1 (GSTO1) protein as a novel tumor-associated antigen and its autoantibody in human esophageal squamous cell carcinoma. ". Tumour Biol. 2014. PMID 25085586.
"GSTO1 uncommon genetic variants are associated with recurrent miscarriage risk.". Fertil Steril. 2014. PMID 24417908.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GSTO1 - Cronfa NCBI

[1]

[2]