GZMB

GZMB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1FQ3, 1IAU
Dynodwyr
Cyfenwau	GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
Dynodwyr allanol	OMIM: 123910 HomoloGene: 108184 GeneCards: GZMB
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • serine-type peptidase activity; • serine-type endopeptidase activity; • hydrolase activity;
Cydrannau o'r gell	• cytosol; • bilen; • immunological synapse; • cnewyllyn cell; • mitocondria; • secretory granule; • cytoplasm;
Prosesau biolegol	• cytolysis; • proteolysis; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • natural killer cell mediated cytotoxicity; • GO:0097285 apoptotic process; • granzyme-mediated apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	3002
	n/a
	ENSG00000100453
	n/a
	P10144
	n/a
	NM_004131; NM_001346011
	n/a
	NP_001332940; NP_004122
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GZMB yw GZMB a elwir hefyd yn Granzyme B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GZMB.

C11
HLP
CCPI
CGL1
CSPB
SECT
CGL-1
CSP-B
CTLA1
CTSGL1

Llyfryddiaeth

"Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response. ". Cancer Res. 2017. PMID 28461564.
"Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis. ". J Dermatol Sci. 2016. PMID 27686401.
"Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans. ". PLoS One. 2016. PMID 27310868.
"[Rapid biosynthesis and release of 35 kD granzyme B by NK92 cells bypassing secretory lysosomes]. ". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016. PMID 26927382.
"Increased IL-21 Expression Induces Granzyme B in Peripheral CD5(+) B Cells as a Potential Counter-Regulatory Effect in Primary Sjögren's Syndrome.". Mediators Inflamm. 2016. PMID 26884645.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GZMB - Cronfa NCBI

[1]

[2]