GZMM

GZMM
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2ZGC, 2ZGH, 2ZGJ, 2ZKS
Dynodwyr
Cyfenwau	GZMM, LMET1, MET1, granzyme M
Dynodwyr allanol	OMIM: 600311 HomoloGene: 21099 GeneCards: GZMM
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0070122 peptidase activity; • serine-type peptidase activity; • endopeptidase activity; • serine-type endopeptidase activity; • hydrolase activity; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• extracellular region; • bilen;
Prosesau biolegol	• innate immune response; • marwolaeth celloedd; • cytolysis; • proteolysis; • immune system process; • GO:0097285 apoptotic process; • T cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologau
	3004
	n/a
	ENSG00000197540
	n/a
	P51124
	n/a
	NM_005317; NM_001258351
	n/a
	NP_001245280; NP_005308
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GZMM yw GZMM a elwir hefyd yn Granzyme M (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GZMM.

MET1
LMET1

Llyfryddiaeth

"Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. ". Biochem Biophys Res Commun. 2016. PMID 27133719.
"Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation. ". Clin Immunol. 2014. PMID 24316590.
"Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71. ". J Immunol. 2010. PMID 21059895.
"Granzyme M: characterization with sites of post-translational modification and specific sites of interaction with substrates and inhibitors. ". Mol Biol Rep. 2011. PMID 20107908.
"The cytotoxic protease granzyme M is expressed by lymphocytes of both the innate and adaptive immune system.". Mol Immunol. 2010. PMID 19896187.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GZMM - Cronfa NCBI

[1]

[2]