HAMP

HAMP
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1M4E, 1M4F, 2KEF, 3H0T, 4QAE
Dynodwyr
Cyfenwau	HAMP, HEPC, HFE2B, LEAP1, PLTR, hepcidin antimicrobial peptide
Dynodwyr allanol	OMIM: 606464 HomoloGene: 81623 GeneCards: HAMP
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• hormone activity; • iron ion transmembrane transporter inhibitor activity; • signaling receptor binding;
Cydrannau o'r gell	• cytoplasm; • extracellular region; • apical cortex; • intercalated disc; • extracellular space;
Prosesau biolegol	• negative regulation of iron export across plasma membrane; • negative regulation of intestinal absorption; • positive regulation of receptor internalization; • GO:1901227 negative regulation of transcription by RNA polymerase II; • negative regulation of iron ion transmembrane transporter activity; • response to iron ion; • multicellular organismal iron ion homeostasis; • defense response to bacterium; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of receptor catabolic process; • positive regulation of protein polyubiquitination; • negative regulation of ion transmembrane transporter activity; • cellular iron ion homeostasis; • cellular response to lipopolysaccharide; • GO:0010260 heneiddio; • cellular response to tumor necrosis factor; • liver regeneration; • cellular response to bile acid; • cellular response to interleukin-6; • response to iron ion starvation; • response to vitamin A; • response to erythropoietin; • positive regulation of cell growth involved in cardiac muscle cell development; • response to ethanol; • acute-phase response; • cellular response to X-ray; • response to zinc ion; • negative regulation of iron ion transmembrane transport; • antimicrobial humoral immune response mediated by antimicrobial peptide; • killing of cells of other organism; • defense response to fungus; • regulation of signaling receptor activity; • GO:0072468 signal transduction;
	Sources:Amigo / QuickGO
Orthologau
	57817
	n/a
	ENSG00000105697
	n/a
	P81172
	n/a
	NM_021175
	n/a
	NP_066998
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HAMP yw HAMP a elwir hefyd yn Hepcidin antimicrobial peptide (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HAMP.

HEPC
PLTR
HFE2B
LEAP1

Llyfryddiaeth

"Identification of novel bone morphogenetic protein- responsive elements in a hepcidin promoter. ". FEBS Lett. 2017. PMID 29105755.
"Association of Single-Nucleotide Polymorphism in the Hepcidin Promoter Gene with Susceptibility to Extrapulmonary Tuberculosis. ". Genet Test Mol Biomarkers. 2017. PMID 28530443.
"Hepcidin: Homeostasis and Diseases Related to Iron Metabolism. ". Acta Haematol. 2017. PMID 28514781.
"Reciprocal regulation between hepcidin and erythropoiesis and its therapeutic application in erythroid disorders. ". Exp Hematol. 2017. PMID 28501597.
"Hepcidin plasma levels are not associated with changes in haemoglobin in early rheumatoid arthritis patients.". Scand J Rheumatol. 2017. PMID 28482738.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HAMP - Cronfa NCBI

[1]

[2]