HCN1

HCN1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3U0Z
Dynodwyr
Cyfenwau	HCN1, BCNG-1, BCNG1, EIEE24, HAC-2, hyperpolarization activated cyclic nucleotide gated potassium channel 1, GEFSP10, DEE24
Dynodwyr allanol	OMIM: 602780 HomoloGene: 32093 GeneCards: HCN1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • intracellular cAMP-activated cation channel activity; • identical protein binding; • voltage-gated sodium channel activity; • ion channel activity; • potassium channel activity; • sodium channel activity; • voltage-gated ion channel activity; • voltage-gated potassium channel activity; • voltage-gated cation channel activity; • cAMP binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• axon; • bilen; • dendrite; • Cellbilen; • integral component of membrane; • HCN channel complex; • integral component of plasma membrane;
Prosesau biolegol	• transmembrane transport; • retinal cone cell development; • regulation of ion transmembrane transport; • apical protein localization; • cludo ïon; • sodium ion transport; • regulation of membrane potential; • sodium ion transmembrane transport; • potassium ion transmembrane transport; • potassium ion transport; • protein homotetramerization; • cellular response to cAMP;
	Sources:Amigo / QuickGO
Orthologau
	348980
	n/a
	ENSG00000164588
	n/a
	O60741
	n/a
	NM_021072
	n/a
	NP_066550
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HCN1 yw HCN1 a elwir hefyd yn Hyperpolarization activated cyclic nucleotide gated potassium channel 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5p12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HCN1.

BCNG1
HAC-2
BCNG-1
EIEE24

Llyfryddiaeth

"The magnitudes of hyperpolarization-activated and low-voltage-activated potassium currents co-vary in neurons of the ventral cochlear nucleus. ". J Neurophysiol. 2011. PMID 21562186.
"Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. ". J Neurosci. 2003. PMID 12598605.
"A di-arginine ER retention signal regulates trafficking of HCN1 channels from the early secretory pathway to the plasma membrane. ". Cell Mol Life Sci. 2015. PMID 25142030.
"De novo mutations in HCN1 cause early infantile epileptic encephalopathy. ". Nat Genet. 2014. PMID 24747641.
"HCN1 channels: a new therapeutic target for depressive disorders?". Sci Signal. 2012. PMID 23033536.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HCN1 - Cronfa NCBI

[1]

[2]