HCN2

HCN2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2MPF, 3U10
Dynodwyr
Cyfenwau	HCN2, BCNG-2, BCNG2, HAC-1, hyperpolarization activated cyclic nucleotide gated potassium channel 2, hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2, EIG17, FEB2, GEFSP11
Dynodwyr allanol	OMIM: 602781 HomoloGene: 31022 GeneCards: HCN2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • potassium channel activity; • cAMP binding; • sodium channel activity; • voltage-gated ion channel activity; • ion channel activity; • intracellular cAMP-activated cation channel activity; • identical protein binding; • voltage-gated potassium channel activity; • voltage-gated sodium channel activity; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• integral component of membrane; • bilen; • voltage-gated potassium channel complex; • Cellbilen; • integral component of plasma membrane; • HCN channel complex;
Prosesau biolegol	• cellular response to cGMP; • sodium ion transmembrane transport; • sodium ion transport; • cell-cell signaling; • regulation of membrane potential; • regulation of ion transmembrane transport; • cludo ïon; • potassium ion transport; • transmembrane transport; • potassium ion transmembrane transport; • cellular response to cAMP; • membrane depolarization during cardiac muscle cell action potential; • sodium ion import across plasma membrane; • potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologau
	610
	n/a
	ENSG00000099822
	n/a
	Q9UL51
	n/a
	NM_001194
	n/a
	NP_001185
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HCN2 yw HCN2 a elwir hefyd yn Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HCN2.

BCNG2
HAC-1
BCNG-2

Llyfryddiaeth

"Dual expression of constitutively active Gαs-protein-coupled receptors differentially establishes the resting activity of the cAMP-gated HCN2 channel in a single compartment. ". Biochem Biophys Res Commun. 2017. PMID 29054409.
"Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening. ". Int J Oncol. 2016. PMID 27212063.
"Isoform dependent regulation of human HCN channels by cholesterol. ". Sci Rep. 2015. PMID 26404789.
"Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart. ". Circ Arrhythm Electrophysiol. 2015. PMID 26304511.
"HCN2 channels account for mechanical (but not heat) hyperalgesia during long-standing inflammation.". Pain. 2014. PMID 24525276.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HCN2 - Cronfa NCBI

[1]

[2]