HEY1

HEY1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2DB7
Dynodwyr
Cyfenwau	HEY1, BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1, hes related family bHLH transcription factor with YRPW motif 1, NERP2
Dynodwyr allanol	OMIM: 602953 HomoloGene: 7756 GeneCards: HEY1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• microsatellite binding; • DNA binding; • protein dimerization activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • transcription factor binding; • GO:0000983 RNA polymerase II general transcription initiation factor activity; • GO:0001948, GO:0016582 protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001106 transcription corepressor activity; • sequence-specific DNA binding; • sequence-specific double-stranded DNA binding;
Cydrannau o'r gell	• cytoplasm; • nucleoplasm; • cnewyllyn cell;
Prosesau biolegol	• dorsal aorta morphogenesis; • pulmonary valve morphogenesis; • negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • heart trabecula formation; • regulation of vasculogenesis; • cardiac septum morphogenesis; • ventricular septum morphogenesis; • labyrinthine layer blood vessel development; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • endocardial cushion morphogenesis; • multicellular organism development; • atrioventricular valve formation; • arterial endothelial cell differentiation; • cellular response to glucocorticoid stimulus; • umbilical cord morphogenesis; • negative regulation of transcription regulatory region DNA binding; • angiogenesis; • GO:0045996 negative regulation of transcription, DNA-templated; • cardiac ventricle morphogenesis; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of Notch signaling pathway; • cardiac epithelial to mesenchymal transition; • Notch signaling involved in heart development; • Notch signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • blood vessel development; • heart development; • cell differentiation; • regulation of neurogenesis; • GO:1901313 positive regulation of gene expression; • negative regulation of biomineral tissue development; • anterior/posterior pattern specification; • negative regulation of neuron differentiation; • circulatory system development;
	Sources:Amigo / QuickGO
Orthologau
	23462
	n/a
	ENSG00000164683
	n/a
	Q9Y5J3
	n/a
	NM_012258; NM_001040708; NM_001282851
	n/a
	NP_001035798; NP_001269780; NP_036390
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HEY1 yw HEY1 a elwir hefyd yn Hes related family bHLH transcription factor with YRPW motif 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q21.13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HEY1.

CHF2
OAF1
HERP2
HESR1
HRT-1
hHRT1
BHLHb31

Llyfryddiaeth

"Identification and characterization of the Hesr1/Hey1 as a candidate trans-acting factor on gene expression through the 3' non-coding polymorphic region of the human dopamine transporter (DAT1) gene. ". J Biochem. 2005. PMID 15749835.
"Hey1, a mediator of notch signaling, is an androgen receptor corepressor. ". Mol Cell Biol. 2005. PMID 15684393.
"Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone. ". Bone. 2010. PMID 19857617.
"A role for the transcription factor HEY1 in glioblastoma. ". J Cell Mol Med. 2009. PMID 18363832.
"Protective effects of transcription factor HESR1 on retinal vasculature.". Microvasc Res. 2006. PMID 17028039.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HEY1 - Cronfa NCBI

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[2]