HHEX

HHEX
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2E1O
Dynodwyr
Cyfenwau	HHEX, HEX, HMPH, HOX11L-PEN, PRH, PRHX, hematopoietically expressed homeobox
Dynodwyr allanol	OMIM: 604420 HomoloGene: 31110 GeneCards: HHEX
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• sequence-specific DNA binding; • DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • protein homodimerization activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • HMG box domain binding; • transcription factor binding; • chromatin binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001948, GO:0016582 protein binding; • eukaryotic initiation factor 4E binding; • TBP-class protein binding; • DNA binding, bending; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • protein-DNA complex; • cnewyllyn cell;
Prosesau biolegol	• Notch signaling pathway; • myeloid leukocyte differentiation; • endoderm development; • DNA conformation change; • GO:0009373 regulation of transcription, DNA-templated; • primary lung bud formation; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • multicellular organism growth; • embryonic organ development; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • negative regulation of vascular endothelial growth factor receptor signaling pathway; • interkinetic nuclear migration; • negative regulation of transcription by competitive promoter binding; • hepatocyte differentiation; • in utero embryonic development; • GO:1901227 negative regulation of transcription by RNA polymerase II; • Wnt signaling pathway; • tissue morphogenesis; • mRNA export from nucleus; • transcription, DNA-templated; • embryonic heart tube development; • vasculogenesis; • morphogenesis of an epithelium; • poly(A)+ mRNA export from nucleus; • positive regulation of Wnt signaling pathway; • forebrain morphogenesis; • multicellular organism development; • hepatoblast differentiation; • thyroid gland development; • common bile duct development; • regulation of cell population proliferation; • protein localization to nucleus; • gall bladder development; • negative regulation of angiogenesis; • pancreas development; • animal organ morphogenesis; • B cell differentiation; • hepatic duct development; • liver development; • negative regulation of transcription by transcription factor localization; • forebrain development; • cell population proliferation; • GO:0045996 negative regulation of transcription, DNA-templated; • primitive streak formation; • anterior/posterior pattern specification; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0072468 signal transduction; • response to peptide hormone; • response to wounding; • cell differentiation; • hemopoiesis; • regulation of leukocyte proliferation;
	Sources:Amigo / QuickGO
Orthologau
	3087
	n/a
	ENSG00000152804
	n/a
	Q03014
	n/a
	NM_002729
	n/a
	NP_002720
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HHEX yw HHEX a elwir hefyd yn Hematopoietically expressed homeobox (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q23.33.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HHEX.

HEX
PRH
HMPH
PRHX
HOX11L-PEN

Llyfryddiaeth

"HHEX: A Crosstalker between HCMV Infection and Proliferation of VSMCs. ". Front Cell Infect Microbiol. 2016. PMID 27965937.
"Screening of HHEX Mutations in Chinese Children with Thyroid Dysgenesis. ". J Clin Res Pediatr Endocrinol. 2016. PMID 26757609.
"The HHEX gene is not related to congenital heart disease in 296 Chinese patients. ". World J Pediatr. 2013. PMID 23929257.
"Hematopoietically-expressed homeobox gene three widely-evaluated polymorphisms and risk for diabetes: a meta-analysis. ". PLoS One. 2012. PMID 23166797.
"Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes.". Leuk Res. 2012. PMID 22874537.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HHEX - Cronfa NCBI

[1]

[2]