HLA-B

HLA-B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3VCL, 4U1H, 4U1K, 5EO1, 5EO0,%%s1AGB, 1AGC, 1AGD, 1AGE, 1AGF, 1M05, 1MI5, 3FFC, 3SJV, 3SKM, 3SKO, 3SPV, 3X13, 3X14, 4QRP, 4QRQ, 4QRS, 4QRT, 4QRU,%%s4O2C, 4O2E, 4O2F,%%s3LN4, 3LN5,%%s4U1J, 4U1M, 4U1N,%%s4U1I, 4U1L, 4U1S,%%s1HSA, 1JGD, 1JGE, 1K5N, 1OF2, 1OGT, 1UXS, 1UXW, 1W0V, 1W0W, 2A83, 2BSR, 2BSS, 2BST, 3B3I, 3B6S, 3BP4, 3BP7, 3CZF, 3D18, 3DTX, 3HCV, 3LV3, 4G8G, 4G8I, 4G9D, 4G9F, 5DEF, 5DEG,%%s1A1N, 1A9B, 1A9E, 1CG9, 1XH3, 1ZHK, 1ZHL, 1ZSD, 2AK4, 2AXF, 2AXG, 2H6P, 2NW3, 2NX5, 3BW9, 3BWA, 3KWW, 3KXF, 3LKN, 3LKO, 3LKP, 3LKQ, 3LKR, 3LKS, 3MV7, 3MV8, 3MV9, 3VFS, 3VFT, 3VFU, 3VFV, 3VFW, 4LNR, 4PR5, 4PRN, 4QRR,%%s1A1M, 1A1O,%%s2BVO, 2BVP, 2BVQ, 2HJL, 2RFX, 2YPK, 2YPL, 3UPR, 3VH8, 3VRI, 3VRJ, 3WUW, 3X11, 3X12, 5B39, 5B38,%%s4JQV, 4XXC,%%s1XR8, 1XR9, 3C9N,%%s4LCY,%%s1M6O, 1N2R, 1SYV, 3DX6, 3DX7, 3DX8, 3DXA, 3KPL, 3KPM, 3KPN, 3KPO, 3KPP, 3KPQ, 3KPR, 3KPS, 3L3D, 3L3G, 3L3I, 3L3J, 4JQX,%%s1E27, 1E28, 4MJI,%%s3W39
Dynodwyr
Cyfenwau	HLA-B, AS, SPDA1, Bw-47, Bw-50, major histocompatibility complex, class I, B, B-4901, B-5001, HEL-S-83, HLA-B*45ZJ, HLA-B-3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA-Cw, HLA-DRB1
Dynodwyr allanol	HomoloGene: 134029 GeneCards: HLA-B
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• signaling receptor binding; • peptide antigen binding;
Cydrannau o'r gell	• integral component of membrane; • phagocytic vesicle membrane; • Golgi apparatus; • early endosome membrane; • bilen; • Golgi membrane; • Cellbilen; • integral component of plasma membrane; • cell surface; • Reticwlwm endoplasmig; • MHC class I protein complex; • ER to Golgi transport vesicle membrane; • integral component of lumenal side of endoplasmic reticulum membrane; • extracellular exosome; • secretory granule membrane; • recycling endosome membrane;
Prosesau biolegol	• antigen processing and presentation; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • regulation of interleukin-12 production; • interferon-gamma-mediated signaling pathway; • immune system process; • antigen processing and presentation of peptide antigen via MHC class I; • regulation of dendritic cell differentiation; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; • protection from natural killer cell mediated cytotoxicity; • type I interferon signaling pathway; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • regulation of immune response; • regulation of T cell anergy; • GO:0022415 viral process; • regulation of interleukin-6 production; • neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologau
	3106
	n/a
ENSG00000228964; ENSG00000234745; ENSG00000206450; ENSG00000224608; ENSG00000223532;
	ENSG00000232126
	n/a
	P01889
	n/a
	NM_005514
	n/a
	NP_005505
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HLA-B yw HLA-B a elwir hefyd yn HLA class I histocompatibility antigen, B-55 alpha chain, HLA class I histocompatibility antigen, B-54 alpha chain, HLA class I histocompatibility antigen, B-52 alpha chain a HLA class I histocompatibility antigen, B-50 alpha chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.33.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HLA-B.

AS
HLAB
B-4901

Llyfryddiaeth

"Association of the HLA-B*53:01 Allele With Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome During Treatment of HIV Infection With Raltegravir. ". Clin Infect Dis. 2017. PMID 28369189.
"Risk and association of HLA with oxcarbazepine-induced cutaneous adverse reactions in Asians. ". Neurology. 2017. PMID 27913699.
"Human class I major histocompatibility complex alleles determine central nervous system injury versus repair. ". J Neuroinflammation. 2016. PMID 27855706.
"Human Leucocyte Antigen B50 Is Associated with Conversion to Generalized Myasthenia Gravis in Patients with Pure Ocular Onset. ". Med Princ Pract. 2017. PMID 27802446.
"Differences in conformational stability of the two alpha domains of the disease-associated and non-disease-associated subtypes of HLA-B27.". Int J Biol Macromol. 2017. PMID 27693341.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HLA-B - Cronfa NCBI

[1]

[2]