HLA-DMA

HLA-DMA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1HDM, 2BC4, 4FQX, 4GBX
Dynodwyr
Cyfenwau	HLA-DMA, D6S222E, DMA, HLADM, RING6, major histocompatibility complex, class II, DM alpha
Dynodwyr allanol	OMIM: 142855 HomoloGene: 4464 GeneCards: HLA-DMA
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• MHC class II protein complex binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• integral component of membrane; • cell surface; • endosome; • lysosome; • extracellular exosome; • late endosome membrane; • bilen; • lysosomal membrane; • MHC class II protein complex; • intracellular membrane-bounded organelle;
Prosesau biolegol	• antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; • peptide antigen assembly with MHC class II protein complex; • antigen processing and presentation; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • immune system process; • adaptive immune response;
	Sources:Amigo / QuickGO
Orthologau
	3108
	n/a
ENSG00000243215; ENSG00000243719; ENSG00000239463; ENSG00000204257; ENSG00000242361;
	ENSG00000241394; ENSG00000243189; ENSG00000242685
	n/a
	P28067
	n/a
	NM_006120
	n/a
	n/a
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HLA-DMA yw HLA-DMA a elwir hefyd yn HLA class II histocompatibility antigen, DM alpha chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HLA-DMA.

DMA
HLADM
RING6
D6S222E

Llyfryddiaeth

"HLA-DMA polymorphisms differentially affect MHC class II peptide loading. ". J Immunol. 2015. PMID 25505276.
"Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape. ". Immunity. 2005. PMID 15723810.
"Increased expression of intracellular HLA-DM but not on the surface of blood monocyte-derived dendritic cells during maturation. ". Yonsei Med J. 2003. PMID 12728471.
"In vivo and in vitro modulation of HLA-DM and HLA-DO is induced by B lymphocyte activation. ". J Immunol. 2001. PMID 11739502.
"Sequence analysis of two novel HLA-DMA alleles.". Immunogenetics. 1994. PMID 8026867.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HLA-DMA - Cronfa NCBI

[1]

[2]