HLA-DQB1

HLA-DQB1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1JK8, 1S9V, 1UVQ, 2NNA, 4GG6
Dynodwyr
Cyfenwau	HLA-DQB1, CELIAC1, HLA-DQB, IDDM1, major histocompatibility complex, class II, DQ beta 1, HLA-DRB1
Dynodwyr allanol	OMIM: 604305 HomoloGene: 1603 GeneCards: HLA-DQB1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• peptide antigen binding; • MHC class II receptor activity; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• integral component of membrane; • endocytic vesicle membrane; • clathrin-coated endocytic vesicle membrane; • endosome; • Golgi apparatus; • trans-Golgi network membrane; • endoplasmic reticulum membrane; • bilen; • Golgi membrane; • Cellbilen; • transport vesicle membrane; • MHC class II protein complex; • lysosomal membrane; • Reticwlwm endoplasmig; • ER to Golgi transport vesicle membrane; • lysosome; • integral component of lumenal side of endoplasmic reticulum membrane; • endosome membrane;
Prosesau biolegol	• antigen processing and presentation; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • interferon-gamma-mediated signaling pathway; • immunoglobulin production involved in immunoglobulin-mediated immune response; • immune system process; • T cell costimulation; • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; • humoral immune response mediated by circulating immunoglobulin; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • T cell receptor signaling pathway; • adaptive immune response;
	Sources:Amigo / QuickGO
Orthologau
	3119
	n/a
ENSG00000233209; ENSG00000206237; ENSG00000231286; ENSG00000206302; ENSG00000179344;
	ENSG00000231939; ENSG00000225824
	n/a
	P01920
	n/a
	NM_002123; NM_001243961; NM_001243962
	n/a
	NP_001230890; NP_001230891; NP_002114
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HLA-DQB1 yw HLA-DQB1 a elwir hefyd yn Major histocompatibility complex, class II, DQ beta 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HLA-DQB1.

IDDM1
CELIAC1
HLA-DQB

Llyfryddiaeth

"Is there a relationship between narcolepsy, multiple sclerosis and HLA-DQB1*06:02?". Arq Neuropsiquiatr. 2017. PMID 28658402.
"Association of HLA-DQB1 polymorphisms with rheumatoid arthritis: a meta-analysis. ". Postgrad Med J. 2017. PMID 28455285.
"Distribution of HLA-DQB1 in Czech Patients with Central Hypersomnias. ". Arch Immunol Ther Exp (Warsz). 2016. PMID 28083611.
"HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis. ". Iran J Allergy Asthma Immunol. 2016. PMID 27921409.
"DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese.". Front Med. 2016. PMID 27896619.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HLA-DQB1 - Cronfa NCBI

[1]

[2]