HOXA5

HOXA5
Dynodwyr
Cyfenwau	HOXA5, HOX1, HOX1.3, HOX1C, homeobox A5
Dynodwyr allanol	OMIM: 142952 HomoloGene: 40726 GeneCards: HOXA5
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;
Cydrannau o'r gell	• cnewyllyn cell;
Prosesau biolegol	• embryonic skeletal system morphogenesis; • pattern specification process; • skeletal system development; • respiratory system process; • GO:0009373 regulation of transcription, DNA-templated; • multicellular organism growth; • lung development; • trachea morphogenesis; • bronchiole development; • cell-cell signaling involved in mammary gland development; • regulation of mammary gland epithelial cell proliferation; • mammary gland alveolus development; • lung goblet cell differentiation; • transcription, DNA-templated; • mammary gland epithelial cell differentiation; • negative regulation of erythrocyte differentiation; • respiratory gaseous exchange by respiratory system; • trachea cartilage morphogenesis; • embryonic skeletal system development; • morphogenesis of an epithelium; • multicellular organism development; • thyroid gland development; • lobar bronchus epithelium development; • mesenchymal-epithelial cell signaling; • positive regulation of apoptotic process; • intestinal epithelial cell maturation; • negative regulation of angiogenesis; • cartilage morphogenesis; • lung alveolus development; • lung-associated mesenchyme development; • epithelial tube branching involved in lung morphogenesis; • cell migration; • positive regulation of myeloid cell differentiation; • anterior/posterior pattern specification; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	3202
	n/a
	ENSG00000106004
	n/a
	P20719
	n/a
	NM_019102
	n/a
	NP_061975
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HOXA5 yw HOXA5 a elwir hefyd yn Homeobox A5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p15.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HOXA5.

HOX1
HOX1C
HOX1.3

Llyfryddiaeth

"Knockdown of HOXA5 inhibits the tumorigenesis in esophageal squamous cell cancer. ". Biomed Pharmacother. 2017. PMID 27960137.
"Effect of ATRA on the expression of HOXA5 gene in K562 cells and its relationship with cell cycle and apoptosis. ". Mol Med Rep. 2016. PMID 27052693.
"Effect of silencing HOXA5 gene expression using RNA interference on cell cycle and apoptosis in Jurkat cells. ". Int J Mol Med. 2016. PMID 26846409.
"Knockdown of homeobox A5 by small hairpin RNA inhibits proliferation and enhances cytarabine chemosensitivity of acute myeloid leukemia cells. ". Mol Med Rep. 2015. PMID 26397212.
"HOXA5 inhibits metastasis via regulating cytoskeletal remodelling and associates with prolonged survival in non-small-cell lung carcinoma.". PLoS One. 2015. PMID 25875824.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HOXA5 - Cronfa NCBI

[1]

[2]