HOXA9

HOXA9
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1PUF
Dynodwyr
Cyfenwau	HOXA9, ABD-B, HOX1, HOX1.7, HOX1G, homeobox A9
Dynodwyr allanol	OMIM: 142956 HomoloGene: 7766 GeneCards: HOXA9
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• sequence-specific DNA binding; • DNA binding; • GO:0001948, GO:0016582 protein binding; • enzyme binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cydrannau o'r gell	• cnewyllyn cell; • transcription regulator complex; • cytoplasm;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • endothelial cell activation; • transcription, DNA-templated; • multicellular organism development; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • negative regulation of myeloid cell differentiation; • spermatogenesis; • single fertilization; • male gonad development; • anterior/posterior pattern specification; • proximal/distal pattern formation; • regulation of gene expression; • mammary gland development; • embryonic forelimb morphogenesis; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • embryonic skeletal system development; • uterus development; • definitive hemopoiesis;
	Sources:Amigo / QuickGO
Orthologau
	3205
	n/a
	ENSG00000078399
	n/a
	P31269
	n/a
	NM_152739; NM_002142
	n/a
	NP_689952
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HOXA9 yw HOXA9 a elwir hefyd yn Homeobox A9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p15.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HOXA9.

HOX1
ABD-B
HOX1G
HOX1.7

Llyfryddiaeth

"Advanced Glycation End-Products Downregulate HoxA9EC through Activation of Nuclear Factor Kappa B by Reciprocal Interaction. ". J Vasc Res. 2017. PMID 28723696.
"An Epigenomic Approach to Improving Response to Neoadjuvant Cisplatin Chemotherapy in Bladder Cancer. ". Biomolecules. 2016. PMID 27598218.
"HOXA9 is Underexpressed in Cervical Cancer Cells and its Restoration Decreases Proliferation, Migration and Expression of Epithelial-to-Mesenchymal Transition Genes. ". Asian Pac J Cancer Prev. 2016. PMID 27039722.
"Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets. ". Oncogene. 2016. PMID 26028034.
"A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide.". Oncotarget. 2015. PMID 25762636.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HOXA9 - Cronfa NCBI

[1]

[2]