HSD17B1

HSD17B1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1A27, 1BHS, 1DHT, 1EQU, 1FDS, 1FDT, 1FDU, 1FDV, 1FDW, 1I5R, 1IOL, 1JTV, 1QYV, 1QYW, 1QYX, 3DEY, 3DHE, 3HB4, 3HB5, 3KLM, 3KLP, 3KM0
Dynodwyr
Cyfenwau	HSD17B1, EDH17B2, EDHB17, HSD17, SDR28C1, hydroxysteroid (17-beta) dehydrogenase 1, hydroxysteroid 17-beta dehydrogenase 1, E2DH, 17-beta-HSD, 20-alpha-HSD, Hsd17b1
Dynodwyr allanol	OMIM: 109684 HomoloGene: 37303 GeneCards: HSD17B1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• oxidoreductase activity; • catalytic activity; • estradiol 17-beta-dehydrogenase activity; • steroid binding; • NADP+ binding; • estradiol binding;
Cydrannau o'r gell	• cytoplasm; • cytosol;
Prosesau biolegol	• estrogen biosynthetic process; • estrogen metabolic process; • lipid metabolism; • steroid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologau
	3292
	n/a
	ENSG00000108786
	n/a
	P14061
	n/a
	NM_000413; NM_001330219
	n/a
	NP_000404; NP_001317148
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HSD17B1 yw HSD17B1 a elwir hefyd yn Hydroxysteroid 17-beta dehydrogenase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HSD17B1.

E2DH
HSD17
EDHB17
EDH17B2
SDR28C1
17-beta-HSD
20-alpha-HSD

Llyfryddiaeth

"Adrenarche unmasks compound heterozygous 3β-hydroxysteroid dehydrogenase deficiency: c.244G>A (p.Ala82Thr) and the novel 931C>T (p.Gln311*) variant in a non-salt wasting, severely undervirilised 46XY. ". J Pediatr Endocrinol Metab. 2017. PMID 28207417.
"Covalent Immobilization of Human Placental 17β-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications. ". Appl Biochem Biotechnol. 2017. PMID 27933483.
"High mRNA levels of 17β-hydroxysteroid dehydrogenase type 1 correlate with poor prognosis in endometrial cancer. ". Mol Cell Endocrinol. 2017. PMID 27923582.
"17β-hydroxysteroid dehydrogenase type Gene 1937 A > G Polymorphism as a Risk Factor for Cervical Cancer Progression in the Polish Population. ". Pathol Oncol Res. 2017. PMID 27571989.
"Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1.". Mol Cell Endocrinol. 2017. PMID 27544780.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HSD17B1 - Cronfa NCBI

[1]

[2]