HSP90B1

HSP90B1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4NH9
Dynodwyr
Cyfenwau	HSP90B1, ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1, heat shock protein 90kDa beta family member 1, heat shock protein 90 beta family member 1
Dynodwyr allanol	OMIM: 191175 HomoloGene: 2476 GeneCards: HSP90B1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • calcium ion binding; • unfolded protein binding; • low-density lipoprotein particle receptor binding; • GO:0001948, GO:0016582 protein binding; • RNA binding; • protein phosphatase binding; • ATP binding;
Cydrannau o'r gell	• cytosol; • endocytic vesicle lumen; • endoplasmic reticulum lumen; • endoplasmic reticulum membrane; • bilen; • focal adhesion; • GO:0005578 extracellular matrix; • melanosome; • Cellbilen; • endoplasmic reticulum chaperone complex; • extracellular region; • midbody; • Reticwlwm endoplasmig; • perinuclear region of cytoplasm; • extracellular exosome; • cnewyllyn cell; • GO:0009327 protein-containing complex; • collagen-containing extracellular matrix;
Prosesau biolegol	• response to hypoxia; • response to stress; • protein folding in endoplasmic reticulum; • negative regulation of apoptotic process; • receptor-mediated endocytosis; • response to endoplasmic reticulum stress; • toll-like receptor signaling pathway; • regulation of phosphoprotein phosphatase activity; • ATF6-mediated unfolded protein response; • actin rod assembly; • retrograde protein transport, ER to cytosol; • sequestering of calcium ion; • protein folding; • ubiquitin-dependent ERAD pathway; • protein transport; • cellular response to ATP; • post-translational protein modification; • cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	7184
	n/a
	ENSG00000166598
	n/a
	P14625
	n/a
	NM_003299
	n/a
	NP_003290
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HSP90B1 yw HSP90B1 a elwir hefyd yn Heat shock protein 90 beta family member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q23.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HSP90B1.

ECGP
GP96
TRA1
GRP94
HEL35
HEL-S-125m

Llyfryddiaeth

"Heat shock protein 90-β over-expression is associated with poor survival in stage I lung adenocarcinoma patients. ". Int J Clin Exp Pathol. 2015. PMID 26339394.
"Chlamydia-infected cells shed Gp96 to prevent chlamydial re-infection. ". Mol Microbiol. 2015. PMID 26235316.
"The Role of Heat Shock Protein 90B1 in Patients with Polycystic Ovary Syndrome. ". PLoS One. 2016. PMID 27046189.
"A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production. ". Endocrinology. 2016. PMID 26982636.
"Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport.". J Biol Chem. 2016. PMID 26872972.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HSP90B1 - Cronfa NCBI

[1]

[2]