HSPD1

HSPD1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4PJ1
Dynodwyr
Cyfenwau	HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13, heat shock protein family D (Hsp60) member 1
Dynodwyr allanol	OMIM: 118190 HomoloGene: 1626 GeneCards: HSPD1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • chaperone binding; • p53 binding; • single-stranded DNA binding; • ATPase activity; • GO:0001948, GO:0016582 protein binding; • double-stranded RNA binding; • DNA replication origin binding; • ATP binding; • ubiquitin protein ligase binding; • protein folding chaperone activity; • unfolded protein binding; • RNA binding; • hydrolase activity; • high-density lipoprotein particle binding; • enzyme binding; • apolipoprotein binding; • apolipoprotein A-I binding; • lipopolysaccharide binding; • isomerase activity;
Cydrannau o'r gell	• cytoplasm; • cyclin-dependent protein kinase activating kinase holoenzyme complex; • lipopolysaccharide receptor complex; • early endosome; • mitocondria; • clathrin-coated pit; • coated vesicle; • extracellular exosome; • GO:0005578 extracellular matrix; • mitochondrial matrix; • extracellular space; • mitochondrial inner membrane; • cytosol; • Cellbilen; • cell surface; • bilen; • secretory granule; • GO:0009327 protein-containing complex;
Prosesau biolegol	• chaperone-mediated protein complex assembly; • positive regulation of interleukin-12 production; • positive regulation of interleukin-10 production; • protein stabilization; • protein maturation; • positive regulation of macrophage activation; • MyD88-dependent toll-like receptor signaling pathway; • isotype switching to IgG isotypes; • B cell activation; • B cell cytokine production; • response to unfolded protein; • B cell proliferation; • protein folding; • positive regulation of T cell mediated immune response to tumor cell; • protein refolding; • positive regulation of interleukin-6 production; • positive regulation of apoptotic process; • response to cold; • GO:0022415 viral process; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • 'de novo' protein folding; • protein import into mitochondrial intermembrane space; • chaperone-mediated protein folding; • apoptotic mitochondrial changes; • positive regulation of interferon-alpha production; • positive regulation of interferon-gamma production; • T cell activation; • negative regulation of apoptotic process; • positive regulation of T cell activation; • mitochondrion organization;
	Sources:Amigo / QuickGO
Orthologau
	3329
	n/a
	ENSG00000144381
	n/a
	P10809
	n/a
	NM_002156; NM_199440
	n/a
	NP_002147; NP_955472
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HSPD1 yw HSPD1 a elwir hefyd yn Heat shock protein family D (Hsp60) member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q33.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HSPD1.

HLD4
CPN60
GROEL
HSP60
HSP65
SPG13
HSP-60
HuCHA60

Llyfryddiaeth

"27-Hydroxycholesterol upregulates the production of heat shock protein 60 of monocytic cells. ". J Steroid Biochem Mol Biol. 2017. PMID 28549691.
"Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis. ". Sci Rep. 2015. PMID 26672742.
"Tolerization against atherosclerosis using heat shock protein 60. ". Cell Stress Chaperones. 2016. PMID 26577462.
"HSP60: a double edge sword in autoimmunity. ". Oncotarget. 2015. PMID 26431161.
"Anti-citrullinated protein antibodies promote apoptosis of mature human Saos-2 osteoblasts via cell-surface binding to citrullinated heat shock protein 60.". Immunobiology. 2016. PMID 26275591.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HSPD1 - Cronfa NCBI

[1]

[2]