HTR1B

HTR1B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4IAQ, 4IAR
Dynodwyr
Cyfenwau	HTR1B, 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12, 5-HT-1B, 5-HT-1D-beta, 5-hydroxytryptamine receptor 1B
Dynodwyr allanol	OMIM: 182131 HomoloGene: 669 GeneCards: HTR1B
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• G protein-coupled receptor activity; • signal transducer activity; • G protein-coupled serotonin receptor activity; • GO:0001948, GO:0016582 protein binding; • neurotransmitter receptor activity; • serotonin binding; • voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • bilen; • integral component of plasma membrane; • Cellbilen; • calyx of Held; • integral component of presynaptic membrane; • serotonergic synapse; • dendrite;
Prosesau biolegol	• chemical synaptic transmission; • G protein-coupled receptor internalization; • regulation of dopamine secretion; • regulation of behavior; • response to mineralocorticoid; • fasogyfyngiad; • adenylate cyclase-inhibiting serotonin receptor signaling pathway; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • cellular response to alkaloid; • negative regulation of serotonin secretion; • cellular response to temperature stimulus; • negative regulation of synaptic transmission, GABAergic; • protein kinase C-activating G protein-coupled receptor signaling pathway; • drinking behavior; • bone remodeling; • feeding behavior; • response to ethanol; • negative regulation of synaptic transmission, glutamatergic; • GO:0072468 signal transduction; • adwaith i gocên; • positive regulation of vascular associated smooth muscle cell proliferation; • G protein-coupled receptor signaling pathway; • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; • GO:0035737 animal behavior; • presynaptic modulation of chemical synaptic transmission; • regulation of synaptic vesicle exocytosis; • regulation of presynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologau
	3351
	n/a
	ENSG00000135312
	n/a
	P28222
	n/a
	NM_000863
	n/a
	NP_000854
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HTR1B yw HTR1B a elwir hefyd yn 5-hydroxytryptamine receptor 1B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q14.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HTR1B.

S12
5-HT1B
HTR1D2
HTR1DB
5-HT-1B
5-HT1DB
5-HT-1D-beta

Llyfryddiaeth

"Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target. ". Leukemia. 2017. PMID 28193998.
"Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine. ". Prog Neuropsychopharmacol Biol Psychiatry. 2017. PMID 28025020.
"Association between HTR1B alleles and suicidal ideation in individuals with major depressive disorder. ". Neurosci Lett. 2017. PMID 28007644.
"A family-based association study of the HTR1B gene in eating disorders. ". Rev Bras Psiquiatr. 2016. PMID 27579596.
"HTR1B gene variants associate with the susceptibility of Raynauds' phenomenon in workers exposed hand-arm vibration.". Clin Hemorheol Microcirc. 2016. PMID 26639766.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HTR1B - Cronfa NCBI

[1]

[2]