HTR2B

HTR2B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4NC3, 4IB4
Dynodwyr
Cyfenwau	HTR2B, 5-HT(2B), 5-HT2B, 5-HT-2B, 5-hydroxytryptamine receptor 2B
Dynodwyr allanol	OMIM: 601122 HomoloGene: 55492 GeneCards: HTR2B
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• G protein-coupled receptor activity; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; • signal transducer activity; • G protein-coupled serotonin receptor activity; • G-protein alpha-subunit binding; • serotonin binding; • neurotransmitter receptor activity;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • bilen; • Cellbilen; • synapse; • cell junction; • neuron projection; • integral component of plasma membrane; • nucleoplasm; • dendrite;
Prosesau biolegol	• intestine smooth muscle contraction; • smooth muscle contraction; • G protein-coupled receptor internalization; • release of sequestered calcium ion into cytosol; • regulation of behavior; • positive regulation of endothelial cell proliferation; • positive regulation of MAP kinase activity; • phosphorylation; • GO:0032737 positive regulation of cytokine production; • fasogyfyngiad; • ERK1 and ERK2 cascade; • positive regulation of phosphatidylinositol biosynthetic process; • cardiac muscle hypertrophy; • heart morphogenesis; • cellular calcium ion homeostasis; • neural crest cell differentiation; • negative regulation of apoptotic process; • negative regulation of cell death; • activation of phospholipase C activity; • protein kinase C signaling; • cGMP biosynthetic process; • cellular response to temperature stimulus; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • heart development; • positive regulation of nitric-oxide synthase activity; • protein kinase C-activating G protein-coupled receptor signaling pathway; • embryonic morphogenesis; • serotonin receptor signaling pathway; • neural crest cell migration; • positive regulation of cell population proliferation; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • phosphatidylinositol 3-kinase signaling; • negative regulation of autophagy; • positive regulation of cell division; • calcium-mediated signaling; • GO:0072468 signal transduction; • phospholipase C-activating G protein-coupled receptor signaling pathway; • G protein-coupled serotonin receptor signaling pathway; • G protein-coupled receptor signaling pathway; • GO:0035737 animal behavior; • cGMP-mediated signaling; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologau
	3357
	n/a
	ENSG00000135914
	n/a
	P41595
	n/a
	NM_000867; NM_001320758
	n/a
	NP_000858; NP_001307687
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HTR2B yw HTR2B a elwir hefyd yn 5-hydroxytryptamine receptor 2B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q37.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HTR2B.

5-HT2B
5-HT-2B
5-HT(2B)

Llyfryddiaeth

"Crystal Structure of an LSD-Bound Human Serotonin Receptor. ". Cell. 2017. PMID 28129538.
"Influence of a HTR2B Stop Codon on Glucagon Homeostasis and Glucose Excursion in Non-Diabetic Men. ". Exp Clin Endocrinol Diabetes. 2016. PMID 27437919.
"The effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males. ". J Psychiatr Res. 2016. PMID 27420381.
"Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients. ". Oncotarget. 2016. PMID 27013593.
"Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis.". Acta Neuropathol. 2016. PMID 26744351.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HTR2B - Cronfa NCBI

[1]

[2]