IFI16 |
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Dynodwyr |
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Cyfenwau | IFI16, IFNGIP1, PYHIN2, interferon gamma inducible protein 16 |
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Dynodwyr allanol | OMIM: 147586 HomoloGene: 115929 GeneCards: IFI16 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • identical protein binding • double-stranded DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • transcription factor binding • GO:0001948, GO:0016582 protein binding • RNA binding
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Cydrannau o'r gell | • nucleolus • nucleoplasm • cnewyllyn cell • bilen • nuclear speck • cytoplasm • cytosol
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Prosesau biolegol | • positive regulation of type I interferon production • GO:0032737 positive regulation of cytokine production • intrinsic apoptotic signaling pathway by p53 class mediator • cellular response to glucose starvation • transcription, DNA-templated • negative regulation of viral genome replication • negative regulation of innate immune response • monocyte differentiation • cellular response to ionizing radiation • negative regulation of DNA binding • regulation of autophagy • myeloid cell differentiation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • GO:0097285 apoptotic process • hemopoiesis • activation of cysteine-type endopeptidase activity • autophagy • negative regulation of cysteine-type endopeptidase activity • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of interleukin-1 beta production • GO:0009373 regulation of transcription, DNA-templated • regulation of gene expression, epigenetic • cell population proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • activation of innate immune response • immune system process • inflammatory response • GO:0045996 negative regulation of transcription, DNA-templated • innate immune response • defense response to virus • cellular response to interferon-beta
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn IFI16 yw IFI16 a elwir hefyd yn Gamma-interferon-inducible protein 16 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q23.1.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IFI16.
- "IFI16 restoration in hepatocellular carcinoma induces tumour inhibition via activation of p53 signals and inflammasome. ". Cell Prolif. 2017. PMID 28990231.
- "Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β Expression. ". J Immunol. 2017. PMID 28893956.
- "IFI16 reduced expression is correlated with unfavorable outcome in chronic lymphocytic leukemia. ". APMIS. 2017. PMID 28517553.
- "Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-β Responses. ". PLoS Pathog. 2016. PMID 27764250.
- "Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency.". J Virol. 2016. PMID 27466416.