IGF2R

IGF2R
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1E6F, 1GP0, 1GP3, 1GQB, 1JPL, 1JWG, 1LF8, 2CNJ, 2V5N, 2V5O, 2V5P, 2L29, 2L2A, 2M68, 5IEI, 2M6T
Dynodwyr
Cyfenwau	IGF2R, CD222, CIMPR, M6P-R, MPR1, MPRI, M6P/MPR 300, CI-M6PR, MPR300, insulin like growth factor 2 receptor
Dynodwyr allanol	OMIM: 147280 HomoloGene: 676 GeneCards: IGF2R
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• retinoic acid binding; • insulin-like growth factor binding; • G protein-coupled receptor activity; • transporter activity; • phosphoprotein binding; • insulin-like growth factor-activated receptor activity; • insulin-like growth factor II binding; • mannose binding; • identical protein binding; • enzyme binding; • G-protein alpha-subunit binding; • GO:0001948, GO:0016582 protein binding; • kringle domain binding; • signaling receptor activity;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • endosome; • late endosome; • bilen; • focal adhesion; • clathrin coat; • endocytic vesicle; • integral component of plasma membrane; • cell surface; • lysosomal membrane; • trans-Golgi network; • early endosome; • nuclear envelope lumen; • perinuclear region of cytoplasm; • trans-Golgi network transport vesicle; • lysosome; • extracellular exosome; • cnewyllyn cell; • trans-Golgi network membrane; • transport vesicle; • extracellular space; • Golgi apparatus; • Cellbilen; • clathrin-coated vesicle membrane; • secretory granule membrane; • clathrin-coated vesicle;
Prosesau biolegol	• regulation of apoptotic process; • G protein-coupled receptor signaling pathway; • response to retinoic acid; • post-embryonic development; • receptor-mediated endocytosis; • animal organ regeneration; • spermatogenesis; • positive regulation of apoptotic process; • liver development; • GO:0072468 signal transduction; • insulin-like growth factor receptor signaling pathway; • neutrophil degranulation; • membrane organization; • GO:0015915 transport; • post-Golgi vesicle-mediated transport; • lysosomal transport;
	Sources:Amigo / QuickGO
Orthologau
	3482
	n/a
	ENSG00000197081
	n/a
	P11717
	n/a
	NM_000876
	n/a
	NP_000867
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IGF2R yw IGF2R a elwir hefyd yn Insulin like growth factor 2 receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q25.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IGF2R.

MPR1
MPRI
CD222
CIMPR
M6P-R
MPR300
CI-M6PR
MPR*300
M6P/IGF2R

Llyfryddiaeth

"Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR. ". J Cell Biol. 2017. PMID 28935633.
"Cargo-selective SNX-BAR proteins mediate retromer trimer independent retrograde transport. ". J Cell Biol. 2017. PMID 28935632.
"The association of soluble IGF2R and IGF2R gene polymorphism with type 2 diabetes. ". J Diabetes Res. 2015. PMID 25922844.
"IGF2R expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC. ". Cell Physiol Biochem. 2014. PMID 25402559.
"A high-throughput siRNA screen identifies genes that regulate mannose 6-phosphate receptor trafficking.". J Cell Sci. 2014. PMID 25278553.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IGF2R - Cronfa NCBI

[1]

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